1228879-37-5

Basic information

• Product Name: benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride(dr>98/2)
• Synonyms: benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride(dr>98/2);raceMic 1-Benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride;3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)- (hydrochloride);N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride (1:2);benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride;benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride
• CAS NO: 1228879-37-5
• Molecular Formula: C14H24Cl2N2
• Molecular Weight: 291.25976
• EINECS: -0
• Mol File: 1228879-37-5.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride(dr>98/2)(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride(dr>98/2)(1228879-37-5)
• EPA Substance Registry System: benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride(dr>98/2)(1228879-37-5)

Safety Data

• Hazardous Substances Data: 1228879-37-5(Hazardous Substances Data)

Usage

General Description

Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is a chemical compound that is used in the pharmaceutical industry as a key intermediate in the synthesis of various drugs. It is a white solid with high purity, with a minimum purity of 98% and a maximum impurity of 2%. The compound is a dihydrochloride salt form of benzyl-N,4-dimethylpiperidin-3-amine, which is a tertiary amine derivative. It is used as a building block in the production of pharmaceuticals, including antihistamines and antipsychotic drugs. benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride(dr>98/2) has important applications in the development of new medications and is used as a versatile intermediate in organic synthesis.

Upstream product

• 1354621-59-2 cis-(1-benzyl-4-methyl-piperidin-3-yl)-methyl-amine 
• 1206824-67-0 methyl (1-benzyl-4-methylpiperidin-3-yl)carbamate hydrochloride 
• 3430-27-1 3-amino-4-methylpyridine 
• 1354621-59-2 cis-N-benzyl-3-methoxycarbonylamino-4-methylpiperidine 
• 694495-63-1 O-methyl-N-(4-methylpyridin-3-yl)carbamate 
• 1204176-45-3 cis-3-methoxycarbonylamino-4-methylpiperidine 
• 1615709-89-1 1-benzyl-4-methyl-3-(methylamino)pyridinium bromide 
• 14773-55-8 3-ethoxy-4-methylpyridine 
• 32018-96-5 1-benzyl-4-methyl-piperidin-3-one 
• 3430-22-6 3-Bromo-4-methylpyridin 
• 142918-38-5 3-methoxy-4-methylpyridine 
• 1206824-89-6 tert-butyl methyl(4-methylpiperidin-3-yl)carbamate 

Downstream Products

• 1259404-17-5 tasocitinib 
• 384336-73-6 (3R,4R)-methyl-(4-methyl-piperidin-3-yl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 
• 540737-29-9 Tofacitinib citrate 
• 1260590-51-9 ((3R,4R)-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine dihydrochloride 
• 923036-30-0 N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7-p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 477600-74-1 tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate 
• 923036-25-3 (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine 
• 540737-29-9 tofacitinib citrate 

Relevant articles and documents

Synthesis and application of 1-benzyl-4-methyl-5-alkoxy-1, 2, 3, 6-tetrahydropyridine derivative

The invention relates to the field of synthesis of drug intermediates, in particular to the field of synthesis of key intermediates for preparing anti-rheumatoid arthritis drug tofacitinib, and specifically relates to a 1-benzyl-4-methyl-5-alkoxy-1, 2, 3, 6-tetrahydropyridine compound, a synthetic method thereof, and an application of the 1-benzyl-4-methyl-5-alkoxy 1, 2, 3, 6-tetrahydropyridine compound in preparation of a key intermediate cis-1-benzyl-3-methylamino-4-methyl piperidine of tofacitinib.

Preparation methods of tofacitinib citrate intermediate and tofacitinib citrate

The invention discloses preparation methods of a tofacitinib citrate intermediate and tofacitinib citrate. The preparation method of the tofacitinib citrate intermediate comprises: preparing N-(1-benzyl-4-methyl-1,2,5,6-tetrahydropiperidine-3-yl)acetamide by using 3-amino-4-methyl-pyridine, acetyl chloride, benzyl chloride and sodium borohydride as raw materials; preparing 1-benzyl-N,4-dimethylpiperidine-3-amine by using the N-(1-benzyl-4-methyl-1,2,5,6-tetrahydropiperidine-3-yl)acetamide, hydrochloric acid, methylamine and sodium borohydride as raw materials; and carrying out resolution and dissociation on the 1-benzyl-N,4-dimethylpiperidine-3-amine, and carrying out salt forming with hydrochloric acid to obtain the product. The invention provides the new tofacitinib citrate intermediatepreparation method, wherein the use amount of the catalytic hydrogenation catalyst is reduced in the preparation process of tofacitinib citrate so as to reduce the cost, and the generation of N-alkylated impurities can be well controlled by adopting the isopropanol/water mixed solvent.

Tropsch process for cloth intermediate (3 R, 4 R) - N, 4 - dimethyl -1 - benzyl -3 - amino piperdine and its oxalate salt hydrate of new synthetic method

The invention relates to a supporting france for cloth intermediate (3 R, 4 R) - N, 4 - dimethyl - 1 - benzyl - 3 - amino piperdine and its oxalate salt hydrate of new synthetic method. In order to 3 - amino - 4 - methyl pyridine as the starting material, its amino with orthoformate [...] is generated by the reaction, after after simple concentration, for the metal borohydride reduction to obtain N - methyl derivatives; Boc protection after the, re-covering and into a quaternary ammonium salt, the metal borohydride reduction, then the Rh catalyst for selective hydrogenation, form an enriched (3 R, 4 R - rel -) configuration of compounds, hydrochloric acid/alcohol system deprotected and into salt splitting removing (3 R, 4 S - rel -) isomer to, the resulting (3 R, 4 R - rel -) configuration product for free after L - DTTA obtained through splitting 3 R, 4 R - configuration product; splitting the resulting salts are free after through, into the oxalate purification, to further remove the residual small amount of 3 S, 4 S - isomer so as to obtain a corresponding high-purity and high optical purity (3 R, 4 R) - N, 4 - dimethyl - 1 - benzyl - 3 - amino piperdine. The method of the invention more beneficial for safe, simple and convenient of industrialized scale preparation Tropsch process for cloth intermediate (3 R, 4 R) - N, 4 - dimethyl - 1 - benzyl - 3 - amino piperdine oxalic acid salt hydrate.