3430-22-6 Usage
Description
3-Bromo-4-methylpyridine is an organic compound with the chemical formula C6H6BrN. It is a clear liquid and serves as an intermediate in the synthesis of various pharmaceutical compounds. Its structure features a pyridine ring with a bromine atom at the 3rd position and a methyl group at the 4th position.
Uses
Used in Pharmaceutical Industry:
3-Bromo-4-methylpyridine is used as an intermediate for the synthesis of pyridinyl pyrrole compounds, which act as proton pump inhibitors. These compounds have improved gastric acid secretion suppressive activity, making them valuable in the treatment of conditions related to excessive stomach acid.
Used in the Synthesis of PDE4 Inhibitors:
3-Bromo-4-methylpyridine is used as a building block in the preparation of substituted 4-(2,2-diphenylethyl)pyridine-N-oxides. These compounds serve as potent phosphodiesterase type 4 (PDE4) inhibitors, which have potential applications in the treatment of various inflammatory and autoimmune diseases.
Used in the Synthesis of Benzodiazepine Site Ligands:
3-Bromo-4-methylpyridine is also utilized in the synthesis of benzodiazepine site ligands bearing a tricyclic pyridone moiety for human GABAA receptors. These ligands have potential applications in the treatment of anxiety, insomnia, and other conditions related to the GABAergic system.
Used in the Synthesis of Ascididemin Isomers:
3-Bromo-4-methylpyridine is employed in the synthesis of a novel isomer of ascididemin, a potent anticancer agent. This isomer may exhibit improved pharmacological properties and enhanced efficacy against various types of cancer.
Used in the Synthesis of 3-Bromo-4-Carbonitrile:
Additionally, 3-Bromo-4-methylpyridine is used in the preparation of 3-bromopyridine-4-carbonitrile, which can be further utilized in the synthesis of various pharmaceutical compounds with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 3430-22-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,3 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3430-22:
(6*3)+(5*4)+(4*3)+(3*0)+(2*2)+(1*2)=56
56 % 10 = 6
So 3430-22-6 is a valid CAS Registry Number.
3430-22-6Relevant articles and documents
Preparation method of (S)-4- (C)-3-(S)-bromopyridine (bromopyridine) (by machine translation)
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Paragraph 0017; 0019; 0020; 0022; 0023; 0025, (2020/02/19)
The method disclosed by the invention has, the beneficial, effects :(1) that 4 - the reaction conditions are mild, the treatment is easy 4 - the method is easy to, operate, the, treatment, is easy . and the method is, easy to, operate 4 - and easy to ;(2) operate 4 - pH, 4 . (by machine translation)
Method for synthesizing 3-bromoisonicotinic acid intermediate
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Paragraph 0009, (2019/07/04)
The invention relates to a method for synthesizing a 3-bromoisonicotinic acid intermediate, and belongs to the technical field of pharmaceutical intermediates. The process comprises the following steps: 4-methylpyridine is adopted as a raw material, and the 4-methylpyridine is reacted with bromine under the catalysis of an aluminum trichloride catalyst to form intermediate 3-bromo-4-methylpyridine; and a novel catalyst Co0.27CuO3 is added, oxygen is introduced for oxidization to form the target product 3-bromoisonicotinic acid. According to the method provided by the invention, in the oxidation reaction process, water is used as a solvent, the novel catalyst Co0.27CuO3 is introduced, the oxygen is used as an oxidant to replace a traditional KMnO4 oxidant, so that pollution of heavy metalsto the environment can be avoided; because the novel catalyst is not affected by the reaction environment, catalytic activity of the novel catalyst is not reduced, and after 25 cycles, activity of thecatalyst is not significantly reduced; and the method has the advantages of greatly improving the yield, reducing the costs, improving the safety, saving the energy, and the like, and conforms to modern chemical industry production requirements of a green reaction.
PROCESS FOR THE PREPARATION OF TOFACITINIB AND INTERMEDIATES THEREOF
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Page/Page column 22-23, (2014/07/08)
The present invention provides compounds of Formula III and Formula VI, and processes for their preparation. The present invention further provides use of the compounds of Formula III and Formula VI for the preparation of tofacitinib or isomers or a mixture of isomers or salts thereof.