122948-57-6

Basic information

• Product Name: ethyl 4-(trifluoromethylsulfonyloxy)cyclohex-3-enecarboxylate
• Synonyms: ethyl 4-(trifluoromethylsulfonyloxy)cyclohex-3-enecarboxylate;4-trifluoroMethanesulfonyloxy-3-cyclohexenecarboxylic acid ethyl ester;4-((Trifluoromethanesulfonyl)oxy)-3-cyclohexene-1-carboxylic acid ethyl ester;4-[(Trifluoromethylsulfonyl)oxy]cyclohex-3-ene-1-carboxylic acid ethyl ester
• CAS NO: 122948-57-6
• Molecular Formula: C₁₀H₁₃F₃O₅S
• Molecular Weight: 302.2674296
• Mol File: 122948-57-6.mol
• Article Data: 47

Chemical Properties

• Boiling Point: 325.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ethyl 4-(trifluoromethylsulfonyloxy)cyclohex-3-enecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(trifluoromethylsulfonyloxy)cyclohex-3-enecarboxylate(122948-57-6)
• EPA Substance Registry System: ethyl 4-(trifluoromethylsulfonyloxy)cyclohex-3-enecarboxylate(122948-57-6)

Safety Data

• Hazardous Substances Data: 122948-57-6(Hazardous Substances Data)

Usage

Description

Ethyl 4-(trifluoromethylsulfonyloxy)cyclohex-3-enecarboxylate is an organic compound with the chemical formula C11H15F3O4S. It is a derivative of cyclohexene with a trifluoromethylsulfonyloxy group attached to the 4-position and an ester functional group at the 3-position. ethyl 4-(trifluoromethylsulfonyloxy)cyclohex-3-enecarboxylate is characterized by its potential reactivity and utility in various chemical reactions and applications.

Uses

Used in Pharmaceutical Industry:
Ethyl 4-(trifluoromethylsulfonyloxy)cyclohex-3-enecarboxylate is used as a reactant in the synthesis of dual-acting histone deacetylases (HDACs) and phosphodiesterase 5 (PDE5) inhibitors. These inhibitors have potential applications in the treatment of various diseases, including cancer and erectile dysfunction.
As a reactant in the synthesis of HDAC and PDE5 inhibitors, ethyl 4-(trifluoromethylsulfonyloxy)cyclohex-3-enecarboxylate contributes to the development of novel therapeutic agents that can modulate the activity of these enzymes, thereby affecting cellular processes and potentially leading to improved treatment outcomes for patients.

Upstream product

• 38222-83-2 2,6-di-tert-butyl-4-methylpyridine 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 145100-51-2 N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide 
• 456-64-4 phenyl trifluoromethanesulfonamide 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 1025373-45-8 trifluoromethanesulfonic acid anhydride 

Downstream Products

• 74043-12-2 4-ethoxycarbonyl-1-trimethylsilylmethyl-1-cyclohexene 
• 864934-23-6 2-(4-ethoxycarbonyl-cyclohex-1-enyl)-benzoic acid methyl ester 
• 864934-24-7 2-(4-hydroxymethyl-cyclohex-1-enyl)-benzoic acid methyl ester 
• 864934-33-8 2-(4-aminomethyl-cyclohexyl)-benzoic acid methyl ester 
• 864934-32-7 2-(4-aminomethyl-cyclohex-1-enyl)-benzoic acid methyl ester 
• 864934-53-2 2-{4-[(4-methyl-3-nitro-pyridin-2-ylamino)-methyl]-cyclohexyl}-benzoic acid methyl ester 
• 864934-52-1 2-{4-[(4-methyl-3-nitro-pyridin-2-ylamino)-methyl]-cyclohex-1-enyl}-benzoic acid methyl ester 
• 461720-18-3 4-(3-nitrophenyl)-3-cyclohexenecarboxylic acid ethyl ester 
• 944317-67-3 ethyl 4-(3-chloro-4-fluorophenyl)cycIohex-3-ene-1-carboxylate 
• 444108-39-8 ethyl 4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)-3-cyclohexenecarboxylate 
• 1049004-32-1 (RS)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-cyclohex-3-enecarboxylic acid ethyl ester 
• 260561-48-6 cis-4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid 
• 444108-44-5 ethyl 4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)-3-cyclohexanecarboxylate 
• 468730-61-2 ethyl 4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)-3-cyclohexanecarboxylate 

Relevant articles and documents

2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

2-(1H-lndole-3-carbonyl)-thiazole-4-carboxamide derivatives and the corresponding imidazole, oxazole and thiophene derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 27 to 32 and 59 to 219; examples 1 to 8; compounds 1-1 to 1-97; tables 1-a, 2 and 3).

ASK1 ISOINDOLIN-1-ONE INHIBITORS AND METHODS OF USE THEREOF

Isoindolin-1-one compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoindolin-1-one compound or analogs thereof, in the treatment of disorders characterized by the activ

Cyclic Alkenylsulfonyl Fluorides: Palladium-Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents

A series of low-molecular-weight, compact, and multifunctional cyclic alkenylsulfonyl fluorides were efficiently prepared from the corresponding alkenyl triflates. Palladium-catalyzed sulfur dioxide insertion using the surrogate reagent DABSO effects sulfinate formation, before trapping with an F electrophile delivers the sulfonyl fluorides. A broad range of functional groups are tolerated, and a correspondingly large collection of derivatization reactions are possible on the products, including substitution at sulfur, conjugate addition, and N-functionalization. Together, these attributes suggest that this method could find new applications in chemical biology.