260561-48-6

Basic information

• Product Name: cis-4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid
• Synonyms: cis-4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid
• CAS NO: 260561-48-6
• Molecular Weight: 317.342
• Mol File: 260561-48-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: cis-4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: cis-4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid(260561-48-6)
• EPA Substance Registry System: cis-4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid(260561-48-6)

Safety Data

• Hazardous Substances Data: 260561-48-6(Hazardous Substances Data)

Upstream product

• 7758-19-2 sodium chlorite 
• 513-35-9 2-methyl-but-2-ene 
• 260561-51-1 cis-4-Cyano-4-(8-methoxy-1,4-benzodioxan-5-yl)cyclohexane carbaldehyde 
• 122948-57-6 ethyl 4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-enecarboxylate 
• 190661-82-6 5-bromo-8-methoxy-2,3-dihydrobenzo[b][1,4]dioxine 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 934-00-9 3-methocycatechol 
• 1710-55-0 5-methoxy-2,3-dihydrobenzo[b][1,4]dioxane 
• 39543-27-6 1-(8-methoxy-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)ethan-1-one 
• 444108-41-2 3-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)-1-buten-3-ol 
• 444108-40-1 8-methoxy-2,3-dihydrobenzo[b][1,4]dioxin-5-ylboronic acid 
• 444108-39-8 ethyl 4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)-3-cyclohexenecarboxylate 
• 444108-44-5 ethyl 4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)-3-cyclohexanecarboxylate 
• 444108-43-4 4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)-3-cyclohexenecarboxylic acid 

Downstream Products

• 1018365-12-2 cis-4-Cyano-4-(8-hydroxy-1,4-benzodioxan-5-yl)cyclohexanecarboxylic acid 

Relevant articles and documents

A practical synthesis of the PDE4 inhibitor, KW-4490

A practical and scalable synthesis of a PDE4 inhibitor KW-4490 (1) was developed. This improved synthesis features the construction of the 1-arylcyclohexene (9) by the Diels-Alder reaction followed by a newly established Brnsted acid-promoted hydrocyanation. Subsequent crystallization-induced dynamic resolution enabled the high-yield production of the desired cis-isomer (cis-8). The synthesis was achieved in seven steps in 37% overall yield.

Oxygen-containing heterocyclic compounds

The present invention relates to oxygen-containing heterocyclic compounds represented by the following formula (I): wherein m represents an integer of 0 to 4; R1, R2, R3 and R4 independently represent a hydrogen