1229609-99-7

Basic information

• Product Name: 6-bromo-2,4-diphenylquinazoline
• Synonyms: 6-bromo-2,4-diphenylquinazoline
• CAS NO: 1229609-99-7
• Molecular Weight: 361.241
• Mol File: 1229609-99-7.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 6-bromo-2,4-diphenylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-2,4-diphenylquinazoline(1229609-99-7)
• EPA Substance Registry System: 6-bromo-2,4-diphenylquinazoline(1229609-99-7)

Safety Data

• Hazardous Substances Data: 1229609-99-7(Hazardous Substances Data)

Upstream product

• 39859-36-4 2-amino-5-bromobenzophenone 
• 108-88-3 toluene 
• 100-52-7 benzaldehyde 
• 39263-32-6 2-amino-5-bromobenzonitrile 
• 98-88-4 benzoyl chloride 
• 100-58-3 phenylmagnesium bromide 
• 106-40-1 4-bromo-aniline 
• 189635-01-6 N-(4-bromo-2-cyanophenyl)benzamide 
• 98-80-6 phenylboronic acid 
• 100-46-9 benzylamine 
• 4903-36-0 N-phenyl-benzimidoyl chloride 
• 62-53-3 aniline 
• 19376-65-9 N-phenyl-N'-(phenylmethyl)-benzenecarboximidamide 
• 7702-38-7 N-(4-bromophenyl)benzamide 

Relevant articles and documents

TMSOTf-catalyzed synthesis of substituted quinazolines using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions

In this article, we report an efficient and mild synthetic route for the construction of substituted quinazolines from functionalized 2-aminobenzophenones with various benzaldehydes usingcat. TMSOTf and hexamethyldisilazane (HMDS) under neat, metal-free and microwave irradiation conditions in which gaseous ammonia was formedin situ. This synthetic protocol provided the desired quinazolines with a broad substrate scope in good to excellent yields. Some structures were confirmed by X-ray single-crystal diffraction analysis.

Four-component quinazoline synthesis from simple anilines, aromatic aldehydes and ammonium iodide under metal-free conditions

A four-component procedure for the preparation of substituted quinazolines from anilines, aromatic aldehydes and ammonium iodide is described. The C-H bond ortho to the amino group in anilines was directly functionalized under metal-free conditions. Two a

Palladium-Catalyzed Three-Component Tandem Process: One-Pot Assembly of Quinazolines

The first example of the palladium-catalyzed, three-component tandem reaction of 2-aminobenzonitriles, aldehydes, and arylboronic acids has been developed, providing a new approach for one-pot assembly of diverse quinazolines in moderate to good yields. A noteworthy feature of this method is the tolerance of bromo and iodo groups, which affords versatility for further synthetic manipulations. Preliminary mechanistic experiments indicate that this tandem process involves two possible mechanistic pathways for the formation of quinazolines via catalytic carbopalladation of the cyano group.