1231747-49-1

Basic information

• Product Name: 2-(bromomethyl)-1-fluoro-3-iodobenzene
• Synonyms: 2-(bromomethyl)-1-fluoro-3-iodobenzene
• CAS NO: 1231747-49-1
• Molecular Weight: 314.924
• Mol File: 1231747-49-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(bromomethyl)-1-fluoro-3-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(bromomethyl)-1-fluoro-3-iodobenzene(1231747-49-1)
• EPA Substance Registry System: 2-(bromomethyl)-1-fluoro-3-iodobenzene(1231747-49-1)

Safety Data

• Hazardous Substances Data: 1231747-49-1(Hazardous Substances Data)

Usage

General Description

2-(bromomethyl)-1-fluoro-3-iodobenzene is a chemical compound with the molecular formula C7H5BrFI. It is a derivative of benzene with a fluorine atom at the 1 position, a bromomethyl group at the 2 position, and an iodine atom at the 3 position. 2-(bromomethyl)-1-fluoro-3-iodobenzene is commonly used as a building block in organic synthesis and can be utilized in the production of various pharmaceuticals, agrochemicals, and materials. Its unique structure and functional groups make it a versatile intermediate in the synthesis of complex organic molecules. Additionally, it is important to handle this chemical with caution due to its potentially hazardous properties.

Upstream product

• 911825-94-0 (2-flioro-6-iodophenyl)methanol 
• 111771-08-5 2-fluoro-6-iodobenzoic acid 
• 443-85-6 1-fluoro-3-iodo-2-methylbenzene 

Downstream Products

• 1231747-27-5 C₁₀H₇F₂IN₂ 
• 1092716-83-0 ((3-fluoro-2-(methoxymethyl)phenyl)ethynyl)trimethylsilane 
• 2377354-94-2 tert-butyl 4-fluoro-1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate 

Relevant articles and documents

Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)-H Arylation with a Transient Directing Group

Methylene-selective C-H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) catalysis. We report a Pd(II)-catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)-H arylation of ketones. The reaction utilizes glycine as a transient directing group and a 2-pyridone ligand, which may govern the methylene selectivity by making intimate molecular associations with the substrate during concerted metalation-deprotonation. This reaction is shown to be highly selective for intramolecular methylene C(sp3)-H arylation, thus enabling sequential C(sp3)-H functionalization.

An improved synthesis of a novel α1A partial agonist including a new two-step synthesis of 4-fluoropyrazole

This Letter outlines a new two-step process for the synthesis of 4-fluoropyrazole and its application in an improved synthesis of 4-fluoro-1-[5-fluoro-1-(1H-imidazol-2-yl)-indan-4-ylmethyl]-1H-pyrazole. The original synthesis of 4-fluoro-1-[5-fluoro-1-(1H-imidazol-2-yl)-indan-4-ylmethyl]-1H-pyrazole is also described.