911825-94-0

Basic information

• Product Name: (2-Fluoro-6-iodophenyl)methanol
• Synonyms: (2-Fluoro-6-iodophenyl)methanol;2-Fluoro-6-iodobenzyl alcohol;2-fluoro-6-iodoBenzenemethanol
• CAS NO: 911825-94-0
• Molecular Formula: C₇H₆FIO
• Molecular Weight: 252.0248132
• Mol File: 911825-94-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-Fluoro-6-iodophenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Fluoro-6-iodophenyl)methanol(911825-94-0)
• EPA Substance Registry System: (2-Fluoro-6-iodophenyl)methanol(911825-94-0)

Safety Data

• Hazardous Substances Data: 911825-94-0(Hazardous Substances Data)

Usage

General Description

(2-Fluoro-6-iodophenyl)methanol, also known as FI-Ph-CH2OH, is a chemical compound with the molecular formula C7H6FIO. It is a white to light yellow solid substance and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. FI-Ph-CH2OH is also employed as a synthetic building block in organic chemistry and is valued for its ability to introduce both fluorine and iodine into various organic compounds. Furthermore, it has potential applications in the fields of medicinal chemistry, materials science, and chemical research. Due to its versatile reactivity and functional group compatibility, FI-Ph-CH2OH is a valuable and widely utilized chemical compound in various industries.

Upstream product

• 111771-08-5 2-fluoro-6-iodobenzoic acid 

Downstream Products

• 911825-96-2 2-(Allyloxymethyl)-1-fluoro-3-iodobenzene 
• 146137-72-6 6-fluoro-2-iodobenzaldehyde 
• 1231747-49-1 2-(bromomethyl)-1-fluoro-3-iodobenzene 

Relevant articles and documents

Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)-H Arylation with a Transient Directing Group

Methylene-selective C-H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) catalysis. We report a Pd(II)-catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)-H arylation of ketones. The reaction utilizes glycine as a transient directing group and a 2-pyridone ligand, which may govern the methylene selectivity by making intimate molecular associations with the substrate during concerted metalation-deprotonation. This reaction is shown to be highly selective for intramolecular methylene C(sp3)-H arylation, thus enabling sequential C(sp3)-H functionalization.

F- Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF3-Substituted Indenes

An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes. The success of this strategy hinges upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same molecule, as well as a smooth transmetalation step, which delicately joins together these two different metallic intermediates.

Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol

In this study we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid, isoochracinic acid, and isoochracinol.