1231930-48-5

Basic information

• Product Name: tert-butyl 4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine-1-carboxylate
• CAS NO: 1231930-48-5
• Molecular Weight: 578.665
• Mol File: 1231930-48-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine-1-carboxylate(1231930-48-5)
• EPA Substance Registry System: tert-butyl 4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine-1-carboxylate(1231930-48-5)

Safety Data

• Hazardous Substances Data: 1231930-48-5(Hazardous Substances Data)

Upstream product

• 1231930-37-2 4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole 
• 1231930-42-9 6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 
• 1178566-52-3 4-((6-aminopyridin-3-yl)methyl)piperazine-1-carbamic acid tert-butyl ester 
• 69879-22-7 6-amino-3-pyridinecarbaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 3167-49-5 6-aminonicotinic acid 

Downstream Products

• 1231930-57-6 5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-(piperazin-1-ylmethyl)pyridin-2-yl)pyrimidin-2-amine 

Relevant articles and documents

Pyrimidine derivative as well as preparation method and application thereof

Embodiments of the invention relate to a pyrimidine derivative as well as a preparation method and application thereof. The pyrimidine derivative is selected from a compound as shown in a general formula (I) or a tautomer, an enantiomer, a diastereoisomer, a meracemate or a raceme of the compound, or a mixture of tautomer, the enantiomer, the diastereoisomer, the meracemate or the raceme, or a pharmaceutically acceptable salt or a prodrug of the compound. The pyrimidine derivative shows an excellent CDK inhibition effect and action.

DEGRADATION OF CYCLIN-DEPENDENT KINASE 4/6 (CDK4/6) BY CONJUGATION OF CDK4/6 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE

The present application provides bifunctional compounds, or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 4 (CDK4) and/or cyclin-dependent kinase 6 (CDK6). The present application also relates to methods for the targeted degradation of CDK4 and/or CDK6 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to CDK4 and/or

PROTEIN KINASE INHIBITORS

The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof which is useful in the treatment of cell proliferative diseases.