1232542-24-3 Usage
Description
(5-azaspiro[2.5]oct-8-yl)carbamic acid tert-butyl ester, also known as TBOA, is a potent and selective inhibitor of excitatory amino acid transporters. It is a white solid that is soluble in organic solvents and has a molecular formula of C13H25N3O3. TBOA acts by binding to the glutamate transporter, blocking the reuptake of glutamate in the brain and leading to increased levels of the neurotransmitter in the synaptic cleft. This can result in enhanced excitatory signaling and potential neurotoxicity.
Uses
Used in Pharmaceutical Research:
TBOA is used as a research compound for studying the function of glutamate transporters. Its application is crucial in understanding the role of these transporters in various neurological disorders.
Used in Neurological Disorder Research:
TBOA is used as a research tool to investigate the role of glutamate transporters in neurological disorders such as epilepsy and stroke. By blocking the reuptake of glutamate, TBOA helps researchers observe the effects on excitatory signaling and neurotoxicity, which can provide insights into the development of potential treatments for these conditions.
Used in Drug Development:
In the pharmaceutical industry, TBOA is used as a lead compound in the development of new drugs targeting glutamate transporters. Its potent and selective inhibition of these transporters makes it a valuable starting point for designing more effective and targeted therapies for neurological disorders.
Used in Neuroscience:
TBOA is employed in neuroscience research to study the effects of increased glutamate levels in the synaptic cleft. This can help researchers understand the underlying mechanisms of excitatory signaling and neurotoxicity, which are important factors in the development of various neurological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1232542-24-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,2,5,4 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1232542-24:
(9*1)+(8*2)+(7*3)+(6*2)+(5*5)+(4*4)+(3*2)+(2*2)+(1*4)=113
113 % 10 = 3
So 1232542-24-3 is a valid CAS Registry Number.
1232542-24-3Relevant articles and documents
Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring
Kodimuthali, Arumugam,Pal, Manojit,Prasunamba, Padala Lakshmi
supporting information; experimental part, (2010/11/21)
We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety. Preparation of the aminopiperidine intermediate was carried out by constructing the cyclopropyl ring prior to assembling the piperidine ring.
