1232542-25-4

Basic information

• Product Name: tert-butyl 5-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)5-azaspiro[2.5]octan-8-ylcarbamate
• CAS NO: 1232542-25-4
• Molecular Weight: 465.552
• Mol File: 1232542-25-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 5-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)5-azaspiro[2.5]octan-8-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 5-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)5-azaspiro[2.5]octan-8-ylcarbamate(1232542-25-4)
• EPA Substance Registry System: tert-butyl 5-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)5-azaspiro[2.5]octan-8-ylcarbamate(1232542-25-4)

Safety Data

• Hazardous Substances Data: 1232542-25-4(Hazardous Substances Data)

Upstream product

• 865758-96-9 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile 
• 1232542-24-3 (5-azaspiro[2.5]oct-8-yl)carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring

We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety. Preparation of the aminopiperidine intermediate was carried out by constructing the cyclopropyl ring prior to assembling the piperidine ring.