123392-71-2

Basic information

• Product Name: 2,4-dimethoxy-α-C-methyldesoxybenzoin
• Synonyms: 2,4-dimethoxy-α-C-methyldesoxybenzoin
• CAS NO: 123392-71-2
• Molecular Weight: 270.328
• Mol File: 123392-71-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,4-dimethoxy-α-C-methyldesoxybenzoin(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dimethoxy-α-C-methyldesoxybenzoin(123392-71-2)
• EPA Substance Registry System: 2,4-dimethoxy-α-C-methyldesoxybenzoin(123392-71-2)

Safety Data

• Hazardous Substances Data: 123392-71-2(Hazardous Substances Data)

Upstream product

• 24131-01-9 2,2,5-trimethyl-5-phenyl-1,3-dioxane-4,6-dione 
• 151-10-0 1,3-Dimethoxybenzene 
• 18439-96-8 1-(2-hydroxy-4-methoxyphenyl)-2-phenylethanone 
• 74-88-4 methyl iodide 

Relevant articles and documents

Scandium triflate-catalyzed intramolecular Friedel-Crafts acylation with Meldrum's acids: insight into the mechanism

The intramolecular Friedel-Crafts acylation of arenes with Meldrum's acid derivatives catalyzed by Sc(OTf)3 was reported as a mild and general entry into functionalized 1-indanones. Mechanistic investigations were undertaken to determine the rate-determining step in the acylation sequence using Meldrum's acid, as well as to examine the role of the Lewis acid catalyst. Enolizable Meldrum's acid derivatives react via an acyl ketene intermediate under thermal conditions, while quaternized Meldrum's acid derivatives are thermally stable and only act as effective Friedel-Crafts acylating agents in the presence of a Lewis acid catalyst. The acylation was postulated to proceed through direct acylation of a Lewis acid-activated carbonyl. In the catalytic Friedel-Crafts acylation of Meldrum's acids, triflic acid appeared to be the active catalytic species, with Sc(OTf)3 serving as a very mild and convenient reagent for its delivery.