1234-28-2Relevant articles and documents
Electron density distribution studies as a tool to explore the behaviour of thiourea-based anion receptors
Kirby, Isabelle L.,Pitak, Mateusz B.,Wilson, Claire,Gale, Philip A.,Coles, Simon J.
, p. 2815 - 2826 (2015)
Building on previous studies of anion-receptor complexes based on a urea scaffold substituted symmetrically with electron-withdrawing nitro groups, the electron density distribution in an analogous thiourea receptor complex and the related asymmetrically
A thiourea-based chromoionophore for selective binding and sensing of acetate
Kato, Ryo,Nishizawa, Seiichi,Hayashita, Takashi,Teramae, Norio
, p. 5053 - 5056 (2001)
Highly selective binding and sensing of acetate over various monovalent inorganic anions (MeCO2-?H2PO4- >Cl-, Br-, I-, SCN-, NO3-, HSO
Synthesis, characterization, and pharmacological evaluation of thiourea derivatives
Alghamdi, Saad,Naz, Sumaira,Sahibzada, Muhammad Umar Khayam,Ulbari, Wasim,Umar, Muhammad Naveed,Zahoor, Muhammad
, p. 764 - 777 (2020/07/20)
Thioureas and their derivatives are organosulfur compounds having applications in numerous fields such as organic synthesis and pharmaceutical industries. Symmetric thiourea derivatives were synthesized by the reaction of various anilines with CS2. The synthesized compounds were characterized using the UV-visible and nuclear magnetic resonance (NMR) spectroscopic techniques. The compounds were screened for in vitro inhibition of α-amylase, α-glucosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) enzymes and for their antibacterial and antioxidant potentials. These compounds were fed to Swiss male albino mice to evaluate their toxicological effects and potential to inhibit glucose-6-phosphatase (G6Pase) inhibition. The antibacterial studies revealed that compound 4 was more active against the selected bacterial strains. Compound 1 was more active against 2,2-diphenyl-1-picrylhydrazyl and 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radicals, AChE, BuChE, and α-glucosidase. Compound 2 was more potent against α-amylase and G6Pase. Toxicity studies showed that compound 4 is safe as it exerted no toxic effect on any of the hematological and biochemical parameters or on liver histology of the experimental animals at any studied dose rate. The synthesized compounds showed promising antibacterial and antioxidant potential and were very active (both in vitro and in vivo) against G6Pase and moderately active against the other selected enzymes used in this study.
A simple and straightforward synthesis of phenyl isothiocyanates, symmetrical and unsymmetrical thioureas under ball milling
Zhang, Ze,Wu, Hao-Hao,Tan, Ya-Jun
, p. 16940 - 16944 (2013/09/24)
Promoted by KOH under ball milling, anilines were efficiently transformed into isothiocyanates (in presence of 5.0 equiv. CS2) or symmetrical thioureas (in presence of 1.0 equiv. CS2), without using any other harsh or toxic decomposition reagent. Some in situ generated isothiocyanates can directly "click" with other amines to afford unsymmetrical thioureas.