1234472-77-5

Basic information

• Product Name: C₄₁H₄₉FN₄O₈
• CAS NO: 1234472-77-5
• Molecular Weight: 744.86
• Mol File: 1234472-77-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₁H₄₉FN₄O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₁H₄₉FN₄O₈(1234472-77-5)
• EPA Substance Registry System: C₄₁H₄₉FN₄O₈(1234472-77-5)

Safety Data

• Hazardous Substances Data: 1234472-77-5(Hazardous Substances Data)

Upstream product

• 71989-26-9 Fmoc-Lys(tert-butoxycarbonyl) 
• 148928-15-8 1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-4-carboxylic acid 
• 169243-86-1 (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: Arginine and phenylalanine side chain groups are keys for receptor activity

In the present study, we report the synthesis and biological evaluation of a series of new non-peptide PAR1 mimetic receptor antagonists, based on conformational analysis of the S42FLLR46 tethered ligand (TL) sequence of PAR1. These compounds incorporate the key pharmacophore groups in the TL sequence, guanidyl, amino and phenyl, which are essential for triggering receptor activity. Compounds 5 and 15 (50-100 μM) inhibited both TFLLR-amide (10 μM) and thrombin-mediated (0.5 and 1 U/ml; 5 and 10 μM) calcium signaling in a cultured human HEK cell assay.