123484-12-8

Basic information

• Product Name: 3-Deoxy-3-fluoro-D-ribofuranose 1-acetate 2,5-dibenzoate
• Synonyms: 3-Deoxy-3-fluoro-D-ribofuranose 1-acetate 2,5-dibenzoate;1-O-acetyl-2,5-di-O-benzoyl-3-fluoro-3-deoxy-α,β-D-ribofuranose;1-O -Acetyl-2,5-di-O-benzoyl-3-fluoro-3-deoxy-D-ribofuranoside
• CAS NO: 123484-12-8
• Molecular Formula: C₂₁H₁₉FO₇
• Molecular Weight: 402.37
• Mol File: 123484-12-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Deoxy-3-fluoro-D-ribofuranose 1-acetate 2,5-dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Deoxy-3-fluoro-D-ribofuranose 1-acetate 2,5-dibenzoate(123484-12-8)
• EPA Substance Registry System: 3-Deoxy-3-fluoro-D-ribofuranose 1-acetate 2,5-dibenzoate(123484-12-8)

Safety Data

• Hazardous Substances Data: 123484-12-8(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 112695-36-0 methyl 2,5-di-O-benzoyl-3-fluoro-3-deoxy-β-D-ribofuranoside 
• 126716-27-6 methyl 2,5-di-O-benzoyl-3-fluoro-3-deoxy-α-D-ribofuranoside 
• 14645-35-3 methyl 3-fluoro-α-D-3-deoxy-arabinofuranoside 
• 152711-00-7 Methyl 3-deoxy-3-fluoro-β-D-arabinofuranoside 
• 237410-10-5 ((2R,3S,4S,5R)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate 
• 43168-73-6 methyl 2,3-anhydro-β-D-lyxofuranoside 
• 26532-10-5 methyl 2,3-anhydro-α-D-lyxofuranoside 
• 51754-99-5 Methyl 3,5-O-Isopropylidene-β-D-xylofuranoside 
• 7045-40-1 Methyl 3,5-O-Isopropylidene-α-D-xylofuranoside 
• 237410-13-8 ((2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate 
• 96622-64-9 Methyl-2-O-tosyl-β-D-xylofuranosid 
• 22834-71-5 Methyl-2-O-tosyl-α-D-xylofuranosid 
• 551929-56-7 Toluene-4-sulfonic acid (2R,3R,4R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-fluoro-2-methoxy-tetrahydro-furan-3-yl ester 

Downstream Products

• 133776-13-3 C₂₃H₂₀FN₃O₆ 
• 133776-14-4 C₂₆H₂₂FN₅O₇ 
• 112668-60-7 N6-benzoyl-9-(2'-O-benzoyl-3'-deoxy-3'-fluoro-β-D-ribofuranosyl)adenine 
• 133776-15-5 C₃₆H₄₂FN₅O₇ 
• 133776-16-6 C₃₆H₄₂FN₅O₇ 
• 112668-58-3 1-(2,5-di-O-benzoyl-3-deoxy-3-fluoro-β-D-ribofuranosyl)uracil 
• 133776-12-2 C₂₃H₁₉FN₂O₇ 
• 122654-35-7 C₂₄H₁₇Cl₂FN₄O₅ 
• 75059-22-2 (2R,3S,4S,5R)-2-(6-amino-9H-purine-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol 
• 551929-59-0 C₃₁H₂₄ClFIN₅O₅ 
• 551929-60-3 C₂₅H₂₁ClFN₅O₅ 
• 243458-51-7 Methyl 5-nitro-1-(2',5'-di-O-benzoyl-3'-fluoro-3'-deoxy-β-D-ribofuranosyl)imidazole-4-carboxylate 
• 243458-50-6 Methyl 4-nitro-1-(2',5'-di-O-benzoyl-3'-fluoro-3'-deoxy-β-D-ribofuranosyl)imidazole-5-carboxylate 
• 123402-20-0 3'-deoxy-3'-fluorocytidine 

Relevant articles and documents

NOVEL STING AGONISTS

The present invention provides compounds of Formula I′: wherein , W, X, Y, Z, Z1, Z2, R1, R2, R3, R4 and R5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the STING protein and thus can be used as medicaments for treating or preventing disorders affected by the agonism of STING.

Design, synthesis and binding affinity of 3′-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands

Several 3′-fluoro analogues, 1a, 1b, and 1c of selective and potent adenosine A3 receptor agonist, Cl-IB-MECA were synthesized from D-xylose via highly regioselective opening of lyxo-epoxides, 8a and 8b with fluoride anion. Compared to the high binding affinity of Cl-IB-MECA to the A3 adenosine receptor, the corresponding 3′-fluoro derivative showed remarkably decreased binding affinity, indicating that 3′-hydroxyl group acts as hydrogen bonding acceptor, not hydrogen bonding donor like fluorine atom in binding to the A3 adenosine receptor.

Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases

A series of 3'-deoxy-3'-fluoro- and 2'-azido-2',3'-dideoxy-3'-fluoro-D-ribofuranosides of natural heterocyclic bases have been synthesized with the use of universal carbohydrate precursors, viz., 1-O-acetyl-2,5-di-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose