123632-35-9

Basic information

• Product Name: 2-Pyrrolidinone, 4-(4-chlorophenyl)-, (4R)-
• CAS NO: 123632-35-9
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.648
• Mol File: 123632-35-9.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinone, 4-(4-chlorophenyl)-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 4-(4-chlorophenyl)-, (4R)-(123632-35-9)
• EPA Substance Registry System: 2-Pyrrolidinone, 4-(4-chlorophenyl)-, (4R)-(123632-35-9)

Safety Data

• Hazardous Substances Data: 123632-35-9(Hazardous Substances Data)

Usage

General Description

2-Pyrrolidinone, 4-(4-chlorophenyl)-, (4R)- is a chemical compound that belongs to the class of pyrrolidinones. It is specifically the (4R) enantiomer of 4-(4-chlorophenyl)-2-pyrrolidinone, which is used in the synthesis of various pharmaceuticals and drugs. This chemical is a chiral compound, with the (4R) enantiomer having specific properties and reactivity compared to its (4S) counterpart. The presence of the 4-chlorophenyl group in the compound can impart specific pharmacological activities or biological effects when incorporated into drug molecules. Overall, this chemical is important in medicinal chemistry and drug development as a building block for synthesizing biologically active compounds.

Upstream product

• 201347-18-4 (3S,4R)-4-(4-Chloro-phenyl)-1-(4-nitro-phenyl)-2-oxo-pyrrolidine-3-carboxylic acid methyl ester 
• 894421-57-9 (Z)-ethyl 4-azido-3-(4-chlorophenyl)but-2-enoate 
• 852051-18-4 methyl (R)-(+)-3-(4-chlorophenyl)-4-nitrobutanoate 
• 750649-46-8 (3R,3'R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate 
• 537676-64-5 ethyl 4-azido-3-(4-chlorophenyl)-2-butenoate 
• 537676-63-4 ethyl (3R)-3-cyano-3-(4-chlorophenyl)propanoate 
• 321575-57-9 (R)-phenyl 3-(4-chlorophenyl)-4-nitrobutanoate 
• 81187-93-1 4-(4-chlorophenyl)-1,5-dihydro-2H-pyrrol-2-one 
• 52927-44-3 dimethyl 2-(4-chlorobenzylidene)malonate 
• 360072-54-4 methyl 2-carbomethoxy-4-nitro-3-(4-chloro-phenyl)-butyrate 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 140-53-4 p-chlorobenzyl cyanide 
• 1256161-69-9 methyl (4R)-4-(4-chlorophenyl)-2-oxopyrrolidine-3-carboxylate 
• 761434-42-8 (R)(-)-2-[1-(4-chlorophenyl)-2-nitroethyl]malonic acid dimethyl ester 

Downstream Products

• 63701-55-3 (R)-(-)-baclofen hydrochloride 
• 63701-56-4 (+)-Baclofen hydrochloride 
• 1375081-89-2 (R)-baclofen hydrochloride 
• 69308-37-8 (R)-baclofen 
• 1252761-94-6 tert-butyl (R)-4-(4-chloro-3-iodophenyl)-2-oxopyrrolidine-1-carboxylate 
• 1345248-90-9 C₁₇H₁₉ClN₂O₃ 
• 1252763-20-4 (3R)-3-[3-((1R)-1-(4-pyridyl)ethoxy)-4-chlorophenyl]-4-aminobutanoic acid 
• 1252763-01-1 (R)-4-amino-3-(4-chloro-3-(pyridin-4-ylmethoxy)phenyl)butanoic acid 
• 1345248-84-1 C₁₇H₁₈ClNO₃ 

Relevant articles and documents

Enantioselective conjugate hydrocyanation of α,β-unsaturated N-acylpyrroles catalyzed by chiral lithium(I) phosphoryl phenoxide

Enantioselective conjugate hydrocyanation of α,β-unsaturated N-acylpyrroles with the combined use of Me3SiCN, LiCN, and HCN has been developed in the presence of a chiral lithium(I) phosphoryl phenoxide catalyst. This reaction is useful for a v

Highly Enantioselective Synthesis of Chiral γ-Lactams by Rh-Catalyzed Asymmetric Hydrogenation

A Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system has been identified for the straightforward asymmetric synthesis of chiral γ-lactams. A variety of NH free α,β-unsaturated lactams bearing a β-aryl or β-alkyl substituent were smoothly hydrogenated to

Synthesis and Evaluation of a New 18F-Labeled Radiotracer for Studying the GABAB Receptor in the Mouse Brain

New GABAB agonists, fluoropyridyl ether analogues of baclofen, have been synthesized as potential PET radiotracers. The compound with highest inhibition binding affinity as well as greatest agonist response, (R)-4-amino-3-(4-chloro-3-((2-fluoro