537676-63-4Relevant articles and documents
Asymmetric induction by (S)-4-isopropyl-1-phenylimidazolidin-2-thione in titanium-mediated aldol reactions and its application in enantioselective synthesis of (R)-baclofen
Khatik, Gopal L.,Khurana, Ravi,Kumar, Varun,Nair, Vipin A.
experimental part, p. 3123 - 3132 (2011/10/31)
The usefulness of (S)-4-isopropyl-1-phenylimidazolidin-2-thione as a chiral auxiliary in stereoselective propionate and acetate aldol reactions is discussed. Further, the enantioselective synthesis of (R)-baclofen by acetate aldol reaction using the chiral auxiliary was demonstrated. Georg Thieme Verlag Stuttgart New York.
Enantioselective synthesis of (R)-(-)-baclofen via Ru(II)-BINAP catalyzed asymmetric hydrogenation
Thakur, Vinay V.,Nikalje, Milind D.,Sudalai
, p. 581 - 586 (2007/10/03)
A short and efficient enantioselective synthesis of (R)-(-)-baclofen, a selective GABAB agonist has been described with an overall yield of 26% and 90% ee. Ru(II)-(S)-BINAP catalyzed asymmetric hydrogenations of C=C and C=O groups constitute the key steps in introducing stereogenic centers into the molecule.