1006386-91-9

Basic information

• Product Name: (4R,5S)-4-carbethoxy-5-(4-chlorophenyl)-1,3,2-dioxathiolane 2-oxide
• Synonyms: (4R,5S)-4-carbethoxy-5-(4-chlorophenyl)-1,3,2-dioxathiolane 2-oxide
• CAS NO: 1006386-91-9
• Molecular Weight: 290.724
• Mol File: 1006386-91-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5S)-4-carbethoxy-5-(4-chlorophenyl)-1,3,2-dioxathiolane 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-4-carbethoxy-5-(4-chlorophenyl)-1,3,2-dioxathiolane 2-oxide(1006386-91-9)
• EPA Substance Registry System: (4R,5S)-4-carbethoxy-5-(4-chlorophenyl)-1,3,2-dioxathiolane 2-oxide(1006386-91-9)

Safety Data

• Hazardous Substances Data: 1006386-91-9(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 70200-14-5 ethyl 3-hydroxy-3-(4-chlorophenyl)propanoate 
• 24393-52-0 ethyl (E)-3-(4-chlorophenyl)prop-2-enoate 
• 1006386-90-8 ethyl (2R,3S)-3-(4-chlorophenyl)-2,3-dihydroxypropionate 

Downstream Products

• 537676-63-4 ethyl (3R)-3-cyano-3-(4-chlorophenyl)propanoate 
• 537676-65-6 ethyl (3S)-3-bromo-3-(4-chlorophenyl)propanoate 
• 141545-22-4 (R)-3-hydroxy-3-(4-chlorophenyl)-propionic acid ethyl ester 
• 123632-35-9 (R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 123632-31-5 (S)-(+)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 63701-56-4 (+)-Baclofen hydrochloride 
• 63701-55-3 (R)-(-)-baclofen hydrochloride 
• 1006386-92-0 ethyl (2S,3S)-2-bromo-3-hydroxy-3-(4-chlorophenyl)propanoate 

Relevant articles and documents

Asymmetrie synthesis of (R)-(-)-baclofen via asymmetric dihydroxylation

A short and efficient asymmetric synthesis of (R)-(-)-baclofen, a selective GABAB agonist has been described with an overall yield of 14% and 85% ee. The Os-catalyzed Sharpless asymmetric dihydroxylation of a,β-unsaturated olefin constitutes the key step in introducing stereogenic centers into the molecule.