123852-08-4 Usage
Description
NH-(m-PEG4)2 is a PEG building block that features an amino (NH2) group, which allows it to be reactive with carboxylic acids or activated NHS esters and carbonyls. This versatile molecule is designed to facilitate the formation of stable and biocompatible conjugates, making it a valuable component in various applications across different industries.
Uses
Used in Pharmaceutical Industry:
NH-(m-PEG4)2 is used as a conjugation agent for attaching therapeutic agents to PEG polymers. This enhances the solubility, stability, and bioavailability of the drug, leading to improved pharmacokinetics and therapeutic efficacy.
Used in Bioconjugation:
NH-(m-PEG4)2 is used as a linker molecule for the formation of bioconjugates, such as antibody-drug conjugates or protein-polymer conjugates. The presence of the reactive amino group allows for efficient coupling with various biomolecules, facilitating the development of targeted therapies and diagnostic tools.
Used in Drug Delivery Systems:
NH-(m-PEG4)2 is used as a component in the design of drug delivery systems, such as nanoparticles or hydrogels. The incorporation of this PEG building block into these systems can improve their stability, biocompatibility, and controlled release properties, ultimately enhancing the delivery and efficacy of therapeutic agents.
Used in Diagnostic Imaging:
NH-(m-PEG4)2 is used as a contrast agent in diagnostic imaging techniques, such as magnetic resonance imaging (MRI) or computed tomography (CT). The PEGylation of imaging agents with NH-(m-PEG4)2 can improve their solubility, circulation time, and targeting capabilities, leading to enhanced imaging contrast and diagnostic accuracy.
Used in Cosmetics and Personal Care Industry:
NH-(m-PEG4)2 is used as a component in the formulation of cosmetics and personal care products, such as creams, lotions, and serums. The hydrophilic-lipophilic balance (HLB) provided by the PEG moiety can improve the product's texture, spreadability, and skin feel, while the reactive amino group allows for the incorporation of various active ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 123852-08-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,8,5 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 123852-08:
(8*1)+(7*2)+(6*3)+(5*8)+(4*5)+(3*2)+(2*0)+(1*8)=114
114 % 10 = 4
So 123852-08-4 is a valid CAS Registry Number.
123852-08-4Relevant articles and documents
Synthesis of branched monodisperse oligoethylene glycols and 19f mri-traceable biomaterials through reductive dimerization of azides
Chen, Shizhen,Jiang, Zhong-Xing,Li, Yu,Yang, Hao,Yang, Zhigang,Yuan, Yuan,Zhang, Huaibin,Zhang, Jing,Zhou, Xin
, p. 6778 - 6787 (2020/06/08)
Multifunctionalized and branched M-OEGs represent valuable PEGylation agents, linkers, and scaffolds in biomedicine. However, the tedious synthesis limited their availability and application. We herein present an azide reductive dimerization method for the convenient synthesis of aza-M-OEGs and derivatives, which provides easy access to a variety of multifunctionalized and branched M-OEGs in one step. With this method, hexa-arm M-OEGs with 54 symmetrical fluorines were synthesized in two steps as a water-soluble, self-assemble, 19F MRI sensitive, and biocompatible dendritic biomaterial.
Monodisperse perfluoro-polyethoxylated amphiphilic compounds with two-chain polar head - Preparation and properties
Selve,Ravey,Stebe,El Moudjahid,Moumni,Delpuech
, p. 411 - 428 (2007/10/02)
Monodisperse new surfactant molecules with a two-chain polyoxyethylene (EO) hydrophilic head and a perfluoroalkyl hydrophobic moiety linked together through an amide bond are synthesized by methods allowing large-scale production. Surface tension measurements (γ ~ 20 mN·m-1) show slow organization of the surfactant film at the water/air interface for longer fluorocarbon tail. Values of critical micellar concentrations and comparisons with monosubstituted amide surfactants are consistent with a high hydrophilicity of the amide function, a small influence of branching over hydrophilicity, and a hydrophobicity of each CF2 unit equivalent to 1.7 methylenes (in the analogous hydrogenated surfactants).
