123942-09-6

Basic information

• Product Name: 4-bromo-2,5-difluorobenzoic acid chloride
• Synonyms: 4-bromo-2,5-difluorobenzoic acid chloride
• CAS NO: 123942-09-6
• Molecular Weight: 255.446
• Mol File: 123942-09-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-bromo-2,5-difluorobenzoic acid chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2,5-difluorobenzoic acid chloride(123942-09-6)
• EPA Substance Registry System: 4-bromo-2,5-difluorobenzoic acid chloride(123942-09-6)

Safety Data

• Hazardous Substances Data: 123942-09-6(Hazardous Substances Data)

Upstream product

• 327-51-5 1,4-dibromo-2,5-difluorobenzene 
• 28314-82-1 4-bromo-2,5-difluorobenzoic acid 

Downstream Products

• 764648-61-5 2-(4-bromo-2,5-difluorophenyl)-4-chloro-6-methylpyrimidine 
• 764648-62-6 2-(4-bromo-2,5-difluorophenyl)-4-chloro-6-ethylpyrimidine 
• 1395553-32-8 C₂H₂O₄*C₁₈H₁₅BrF₂N₄O 
• 764649-67-4 (2R)-3-{[2-(4-bromo-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}propane-1,2-diol oxalate 
• 764648-42-2 4-bromo-2,5-difluorobenzamide 
• 1395553-31-7 2-(4-bromo-2,5-difluorophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine 
• 764708-28-3 2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine 
• 133541-45-4 4-bromo-2,5-difluoro-benzonitrile 
• 884534-59-2 3-[(4-bromo-2,5-difluorobenzoyl)amino] thiophene-2-carboxamide 
• 167556-68-5 7-(2,6-Dimethyl-pyridin-4-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 167556-65-2 ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate 
• 167556-70-9 (Z)-2-(4-Bromo-2,5-difluoro-benzoyl)-3-tert-butylamino-acrylic acid ethyl ester 
• 123942-14-3 (Z)-2-(4-Bromo-2,5-difluoro-benzoyl)-3-cyclopropylamino-acrylic acid ethyl ester 
• 123942-13-2 (Z)-2-(4-Bromo-2,5-difluoro-benzoyl)-3-dimethylamino-acrylic acid ethyl ester 

Relevant articles and documents

ANTIBACTERIAL COMPOUNDS

This invention relates to antibacterial and anti-mycobacterial drug compounds of formula (I). It also relates to pharmaceutical formulations of antibacterial drug compounds of formula (I). It also relates to uses of the derivatives in treating bacterial i

TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS

A compound of formula I wherein: n is 1 or 2: p is 0 or 1; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; R6a and R6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.

Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists

Novel 4-amino-2-phenylpyrimidine derivatives were synthesized and evaluated as GPR119 agonists. Optimization of the substituents on the phenyl ring at the 2-position and the amino group at the 4-position led to the identification of 3,4-dihalogenated and