1239470-62-2Relevant articles and documents
Pyrazole derivatives as inhibitors of arachidonic acid-induced platelet aggregation
Levent, Serkan,?ali?kan, Burcu,?ift?i, Murat,?zkan, Ye?im,Yenicesu, Idil,ünver, Hüseyin,Banoglu, Erden
, p. 42 - 53 (2013/07/27)
Antiplatelet drugs are promising therapeutics to intervene with platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischemic stroke. Here, we describe the synthesis and structure-activity relationships of potent inhibitors of platelet aggregation based on the 1,5-diarylpyrazol-3-carboxamide scaffold. Analogs from this series demonstrated potent anti-aggregatory activities against arachidonic acid-induced platelet aggregation, as measured by turbidimetric method of Born. 1,5-Diarylpyrazole-3- carboxamides obtained with small-basic amines (7, 8, 50, 51, 61, 62) displayed the strongest activity with IC50 values in low nanomolar range (5.7-83 nM). On the basis of their high potency in cellular environment, these straightforward pyrazole derivatives may possess potential in the design of more potent compounds for intervention with cardiovascular diseases.