1239861-00-7

Basic information

• Product Name: 4-(2-chloroquinazolin-4-yloxy)-3,5-dimethoxybenzonitrile
• CAS NO: 1239861-00-7
• Molecular Weight: 341.754
• Mol File: 1239861-00-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-chloroquinazolin-4-yloxy)-3,5-dimethoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-chloroquinazolin-4-yloxy)-3,5-dimethoxybenzonitrile(1239861-00-7)
• EPA Substance Registry System: 4-(2-chloroquinazolin-4-yloxy)-3,5-dimethoxybenzonitrile(1239861-00-7)

Safety Data

• Hazardous Substances Data: 1239861-00-7(Hazardous Substances Data)

Upstream product

• 607-68-1 2,4-dichloroquinazoline 
• 72684-95-8 3,5-dimethoxy-4-hydroxybenzonitrile 

Relevant articles and documents

Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy

Molecular hybridization of the known anti-HIV-1 template DPC083 and etravirine based on docking model overlay has been generated a novel series of diarylbenzopyrimidine analogues (DABPs) (5a-z). These new hybrids were assessed for their activity against HIV in MT-4 cell cultures. Most of these compounds showed good activity against wild-type HIV-1 and mutant viruses. In particular, compound 5r showed the most potent activity against wild-type HIV-1 with an EC50 value of 1.8 nM, and with a selectivity index up to 111,954. It also proved more active against mutant L100I, K103N, Y188L, and K103N + Y181C RT HIV-1 strains than efavirenz.