1240283-73-1

Basic information

• Product Name: C₂₀H₁₉NO₃Se
• CAS NO: 1240283-73-1
• Molecular Weight: 400.336
• Mol File: 1240283-73-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₉NO₃Se(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₉NO₃Se(1240283-73-1)
• EPA Substance Registry System: C₂₀H₁₉NO₃Se(1240283-73-1)

Safety Data

• Hazardous Substances Data: 1240283-73-1(Hazardous Substances Data)

Downstream Products

• 1240283-78-6 methyl (3R)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate 
• 58543-97-8 (3R)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoic acid 

Relevant articles and documents

A reasonably stereospecific multistep conversion of Boc-protected α-amino acids to Phth-protected β3-amino acids

A method for the synthesis of β3-amino acids starting from α-amino acids is described. This conversion can be effected by an eight-step procedure which involves the transformation of the carboxylic group into an alkyne followed by a selenium-mediated conversion of the carbon-carbon triple bond to a Se-phenyl selenocarboxylate intermediate. The reactive Se-phenyl selenocarboxylate intermediates can be trapped with water, alcohols or the amine of an amino acid derivative to give β3-amino acids, β3-amino esters or mixed peptides, respectively. The whole transformations of the carboxylic group into an alkyne and of the alkyne group into β3-amino acids may not require purification of the intermediate products but a work-up and isolation procedure of crude materials.