58543-97-8

Basic information

• Product Name: (3R)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoic acid
• CAS NO: 58543-97-8
• Molecular Weight: 261.277
• Mol File: 58543-97-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoic acid(58543-97-8)
• EPA Substance Registry System: (3R)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoic acid(58543-97-8)

Safety Data

• Hazardous Substances Data: 58543-97-8(Hazardous Substances Data)

Upstream product

• 1240283-73-1 C₂₀H₁₉NO₃Se 

Downstream Products

• 5699-54-7 (R)-3-amino-4-methylpentanoic acid 

Relevant articles and documents

A reasonably stereospecific multistep conversion of Boc-protected α-amino acids to Phth-protected β3-amino acids

A method for the synthesis of β3-amino acids starting from α-amino acids is described. This conversion can be effected by an eight-step procedure which involves the transformation of the carboxylic group into an alkyne followed by a selenium-mediated conversion of the carbon-carbon triple bond to a Se-phenyl selenocarboxylate intermediate. The reactive Se-phenyl selenocarboxylate intermediates can be trapped with water, alcohols or the amine of an amino acid derivative to give β3-amino acids, β3-amino esters or mixed peptides, respectively. The whole transformations of the carboxylic group into an alkyne and of the alkyne group into β3-amino acids may not require purification of the intermediate products but a work-up and isolation procedure of crude materials.