1242074-82-3

Basic information

• Product Name: cyclopentyl 1-aminocyclobutanecarboxylate 4-methylbenzenesulfonate
• Synonyms: cyclopentyl 1-aminocyclobutanecarboxylate 4-methylbenzenesulfonate
• CAS NO: 1242074-82-3
• Molecular Weight: 355.455
• Mol File: 1242074-82-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: cyclopentyl 1-aminocyclobutanecarboxylate 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: cyclopentyl 1-aminocyclobutanecarboxylate 4-methylbenzenesulfonate(1242074-82-3)
• EPA Substance Registry System: cyclopentyl 1-aminocyclobutanecarboxylate 4-methylbenzenesulfonate(1242074-82-3)

Safety Data

• Hazardous Substances Data: 1242074-82-3(Hazardous Substances Data)

Upstream product

• 96-41-3 Cyclopentanol 
• 22264-50-2 1-aminocyclobutane-1-carboxylic acid 
• 104-15-4 toluene-4-sulfonic acid 

Relevant articles and documents

BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS

Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.

ENZYME INHIBITORS

Compounds of formula (I), inhibit HDAC activity: wherein A, B and D independently represent =CH- or =N-; W is-CH=CH- Or -CH2CH2-; R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R2 and R3 are selected from the side chains of a natural or non-natural alpha amino acid, provided that neither R2 nor R3 is hydrogen, or R2 and R3, taken together with the carbon to which they are attached, form a 3-6 membered saturated cycloalkyl or heterocyclyl ring; Y is a bond, -C(=O)-, -S(=O)2-, -C(=O)O-, -C(=O)NR'-, -C(=S)-NR', -C(=NH)NR' or -S(=O)2NR - wherein R' is hydrogen or optionally substituted C1-C6 alkyl; L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, Q, AIk1 and AIk2 are as defined in the claims; X1 represents a bond; -C(=O); or -S(=O)2-; -NR4C(=O)-, -C(=O)NR4-,- NR4C(=O)NR5-, -NR4S(=O)2-, or -S(=O)2NR4- wherein R4 and R5 are independently hydrogen or optionally substituted C1-C6 alkyl; and z is 0 or 1.