22264-50-2 Usage
Description
1-Aminocyclobutanecarboxylic acid (ACBC) is a compound that functions as an agonist and an analog of glycine at the N-methyl-D-aspartate (NMDA) receptor site. It plays a significant role in modulating signal transmission within the central nervous system (CNS) by interacting with the NMDA receptor.
Uses
Used in Pharmaceutical Industry:
1-Aminocyclobutanecarboxylic acid is used as a therapeutic agent for its potential in modulating signal transmission in the CNS. As an agonist and analog of glycine at the NMDA receptor site, ACBC can influence various neurological processes and may be utilized in the development of treatments for conditions related to the CNS.
Used in Research and Development:
1-Aminocyclobutanecarboxylic acid is used as a research tool in the field of neuroscience to study the effects of NMDA receptor modulation on signal transmission in the CNS. This can help researchers better understand the underlying mechanisms of various neurological disorders and develop targeted therapies.
Used in Drug Design:
1-Aminocyclobutanecarboxylic acid is used as a lead compound in the design and development of new drugs targeting the NMDA receptor. Its agonist properties and interaction with the glycine site make it a valuable starting point for creating novel therapeutics with potential applications in treating neurological conditions.
Biological Activity
NMDA receptor antagonist acting at the glycine site.
Check Digit Verification of cas no
The CAS Registry Mumber 22264-50-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,6 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 22264-50:
(7*2)+(6*2)+(5*2)+(4*6)+(3*4)+(2*5)+(1*0)=82
82 % 10 = 2
So 22264-50-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H12BrN3/c12-8-1-2-9-10(15-6-4-13)3-5-14-11(9)7-8/h1-3,5,7H,4,6,13H2,(H,14,15)
22264-50-2Relevant articles and documents
Ethylene biosynthesis. 12. Analog approach to the active site topography of the ethylene-forming enzyme. Novel hydroxamate inhibitors
Pirrung,Cao,Chen
, p. 5790 - 5794 (1995)
In order to understand both the substrate specificity and active site topography of the ethylene-forming enzyme (EFE), a number of analogs of its substrate, 1-aminocyclopropanecarboxylic acid, have been prepared and studied as inhibitors. Because of the dependence of EFE activity on iron, hydroxamic acids, a functional group known to bind iron tightly, derived from several small carboxylic/amino acids were studied along with the parent amino acids. The activity of these materials was assayed in vitro against the purified EFE from apple fruit. The varying potency of the amino acid hydroxamates suggests that they do not act simply by binding to iron and removing it from the enzyme. The order of their potency was consistent with the idea that binding reflects both metal chelation and hydrophobic interactions in the active site. The most potent inhibitor, ACC-hydroxamate, has about 1 μM K(i).
ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
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Page/Page column 78, (2011/04/26)
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (Formula (I)), including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
1-CARBAMOYLCYCLOALKYLCARBOXYLIC ACID COMPOUNDS, PROCESSES FRO MAKING AND USES THEREOF
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Page/Page column 18, (2008/06/13)
The invention relates to the field of pharmaceutics and more specifically to novel cycloalkylamidoacid compositions useful in the preparation of cycloalkyaminoacids and oxazolidinediones, and processes for making cycloamidoacids. Formula (1)
