92398-47-5

Basic information

• Product Name: Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)
• Synonyms: Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI);1-Aminocyclobutanecarboxylicacidmethylesterhydrochloride;Methyl 1-aMinocyclobutane carboxylate HCl;Cyclobutanecarboxylic acid, 1-aMino-, Methyl ester, hydrochloride;Methyl 1-aMinocyclobutanecarboxylate hydrochloride
• CAS NO: 92398-47-5
• Molecular Formula: C₆H₁₁NO₂*ClH
• Molecular Weight: 165.61798
• Product Categories: ACIDHALIDE
• Mol File: 92398-47-5.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 206.8°C at 760 mmHg
• Flash Point: 78.9°C
• Appearance: /
• Vapor Pressure: 0.194mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)(92398-47-5)
• EPA Substance Registry System: Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)(92398-47-5)

Safety Data

• Hazardous Substances Data: 92398-47-5(Hazardous Substances Data)

Usage

Uses

Used as a primary and secondary intermediate for pharmaceutical and organic synthesis.

InChI:InChI=1/C6H11NO2.ClH/c1-9-5(8)6(7)3-2-4-6;/h2-4,7H2,1H3;1H

Upstream product

• 67-56-1 methanol 
• 22264-50-2 1-aminocyclobutane-1-carboxylic acid 
• 89691-88-3 1,3-diazaspiro[4.3]octane-2,4-dione 

Downstream Products

• 92398-61-3 N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-α-aminocyclobutanecarboxylic acid methyl ester 
• 90058-40-5 1-(2-Benzyloxycarbonylamino-acetylamino)-cyclobutanecarboxylic acid methyl ester 
• 90058-41-6 cyclo(glycyl-1-amino-1-cyclobutanecarbonyl) 
• 744159-31-7 1-(2-Amino-propionylamino)-cyclobutanecarboxylic acid methyl ester 
• 744159-31-7 1-(2-Amino-propionylamino)-cyclobutanecarboxylic acid methyl ester 

Relevant articles and documents

A two-aryl thio hydantoin derivatives and use thereof

The invention provides a novel diarylthiohydantoin derivative with the structure represented by formula I, and its application. In the formula, X is O or S; R1 and R2 can bee same to or different from each other, respectively represent hydrogen, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-8 naphthenic base, and a C3-8 alkenyl group; R3 represents hydrogen, halogen atoms, a hydroxyl group, a cyano group and a nitro group; R4 and R5 can be same to or different from each other, and respectively represent hydrogen, halogen atoms, -C=(O)-N-(C1-4alkyl) and -(C1-4alkyl)-C(=O)-N-(C1-4 alkyl); and n is 1, 2, 3, or 4. The invention also relates to the application of the above compounds in excessive proliferative diseases.

Carboxamide derivatives, intermediate, preparation method, pharmaceutical composition and application

The invention discloses a formamide derivative, an intermediate, a preparation method, a pharmaceutical composition and an application. The invention provides a formamide derivative shown in a formula 1 as well as pharmaceutically acceptable salt or solvates of the derivative. The formamide derivative disclosed by the invention is an inhibitor of 11 beta-hydroxysteroid dehydrogenase in a type I, can be used for preparing medicines for treating various diseases which are related to expression or activity of 11beta-HSD1, and has a good market development prospect.

A COMPOUND FOR INHIBITING 11B-HYDROXY STEROID DEHYDROGENASE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Disclosed are a novel compound or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including the same for inhibiting human 11-β-hydroxy steroid dehydrogenase type 1 (11β-HSD1). The disclosed compound and the pharmaceutical composition including the same for inhibiting human 11-β-hydroxy steroid dehydrogenase type 1 (11β-HSD1) are excellent in activity and solubility, and is more efficient in formulation and transfer.