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41248-13-9

41248-13-9

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41248-13-9 Usage

Description

1-Hydroxy-cyclobutanecarboxylic acid is an organic compound with the molecular formula C5H6O3. It is a key intermediate in the synthesis of various pharmaceutical compounds and has been identified for its potential applications in the development of novel drugs.

Uses

Used in Pharmaceutical Industry:
1-Hydroxy-cyclobutanecarboxylic acid is used as a key intermediate in the synthesis of piperidines or piperidones substituted with urea and heteroaryl as FPR2 modulators. These FPR2 modulators have potential therapeutic applications in treating various medical conditions, such as inflammatory diseases and metabolic disorders, by modulating the activity of the formyl peptide receptor 2 (FPR2).

Physical Form

Solid

Check Digit Verification of cas no

The CAS Registry Mumber 41248-13-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,2,4 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 41248-13:
(7*4)+(6*1)+(5*2)+(4*4)+(3*8)+(2*1)+(1*3)=89
89 % 10 = 9
So 41248-13-9 is a valid CAS Registry Number.

41248-13-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-hydroxycyclobutane-1-carboxylic acid

1.2 Other means of identification

Product number -
Other names 1-Hydroxy-cyclobutancarbonsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:41248-13-9 SDS

41248-13-9Relevant articles and documents

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Boeeseken,Lutgerhorst

, p. 159,162 (1932)

-

Pyridone-conjugated monobactam antibiotics with gram-negative activity

Brown, Matthew F.,Mitton-Fry, Mark J.,Arcari, Joel T.,Barham, Rose,Casavant, Jeffrey,Gerstenberger, Brian S.,Han, Seungil,Hardink, Joel R.,Harris, Thomas M.,Hoang, Thuy,Huband, Michael D.,Lall, Manjinder S.,Lemmon, M. Megan,Li, Chao,Lin, Jian,McCurdy, Sandra P.,McElroy, Eric,McPherson, Craig,Marr, Eric S.,Mueller, John P.,Mullins, Lisa,Nikitenko, Antonia A.,Noe, Mark C.,Penzien, Joseph,Plummer, Mark S.,Schuff, Brandon P.,Shanmugasundaram, Veerabahu,Starr, Jeremy T.,Sun, Jianmin,Tomaras, Andrew,Young, Jennifer A.,Zaniewski, Richard P.

supporting information, p. 5541 - 5552 (2013/07/26)

Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Rat pharmacokinetic studies with compound 17 demonstrate low clearance and low plasma protein binding. In addition, evidence is provided for a number of analogues suggesting that the siderophore receptors PiuA and PirA play a role in drug uptake in P. aeruginosa strain PAO1.

MONOBACTAMS

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Page/Page column 120-121, (2012/06/16)

The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.

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