124257-73-4

Basic information

• Product Name: 6-(acetylamino)-1,4-dibenzylhexahydro-1H-1,4-diazepine
• CAS NO: 124257-73-4
• Molecular Weight: 337.465
• Mol File: 124257-73-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(acetylamino)-1,4-dibenzylhexahydro-1H-1,4-diazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(acetylamino)-1,4-dibenzylhexahydro-1H-1,4-diazepine(124257-73-4)
• EPA Substance Registry System: 6-(acetylamino)-1,4-dibenzylhexahydro-1H-1,4-diazepine(124257-73-4)

Safety Data

• Hazardous Substances Data: 124257-73-4(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 24225-89-6 2-chloromethyl-1,4-bis(phenylmethyl)piperazine 

Downstream Products

• 129295-48-3 1,4-dibenzyl-1,4-diazepan-6-amine 

Relevant articles and documents

Development of potent serotonin-3 (5-HT3) receptor antagonists. I. Structure-activity relationships of 2-alkoxy-4-amino-5-chlorobenzamide derivatives

A new series of 2-alkoxy-4-amino-5-chlorobenzamide derivatives hearing five- to seven-membered heteroalicyclic rings in the amine moiety was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity by assaying the ability to antagonize the yon Bezold-Jarisch reflex in rats. The five- to seven-membered heteroalicycles comprise pyrrolidine, morpholine, 1,4-thiazine, piperidine, piperazine, 1,4-oxazepine, 1,4- thiazepine, azepine, and 1,4-diazepine rings. Among them, some benzamide derivatives having a 1,4-diazepine ring showed a potent 5-HT3 receptor antagonistic activity. In particular, 4-amino-5-chloro-N-(1,4- dimethylhexahydro-1H-1,4-diazepin-6-yl)-2-ethoxyhenzamide (96) and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 103 showed potent 5-HT3 receptor antagonistic activity without 5-HT4 receptor binding affinity.