129295-48-3

Basic information

• Product Name: 1,4-dibenzyl-1,4-diazepan-6-amine
• Synonyms: 1,4-dibenzyl-1,4-diazepan-6-amine
• CAS NO: 129295-48-3
• Molecular Weight: 295.428
• Mol File: 129295-48-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,4-dibenzyl-1,4-diazepan-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dibenzyl-1,4-diazepan-6-amine(129295-48-3)
• EPA Substance Registry System: 1,4-dibenzyl-1,4-diazepan-6-amine(129295-48-3)

Safety Data

• Hazardous Substances Data: 129295-48-3(Hazardous Substances Data)

Upstream product

• 1173766-86-3 1,4-dibenzyl-6-hydroxymethyl-6-nitroperhydro-1,4-diazepine 
• 140-28-3 N,N'-Dibenzylethylenediamine 
• 24225-89-6 2-chloromethyl-1,4-bis(phenylmethyl)piperazine 
• 1017575-29-9 (6S)-6-amino-1,4-dibenzyl-1,4-diazepan-5-one 
• 124257-73-4 6-(acetylamino)-1,4-dibenzylhexahydro-1H-1,4-diazepine 

Downstream Products

• 454709-85-4 tert-butyl (1,4-diazepan-6-yl)carbamate 
• 129294-09-3 N-[1-(3-methylbenzyl)-4-methylhexahydro-1H-1,4-diazepin-6-yl]-1H-indazole-3-carboxamide 
• 1017576-00-9 1-(1,4-dibenzyl-1,4-diazepan-6-ylaminocarbonyloxy)pyrrolidin-2,5-dione 

Relevant articles and documents

Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor

The dualsteric ligand approach, aiming at ligands with improved subtype selectivity, has been increasingly applied to muscarinic receptors (MRs). In this article, we present the synthesis and characterization of a M2R subtype-preferring radiola

NOVEL INHIBITORS OF BETA-LACTAMASE

A class of 7-oxo-2,6-diazabicyclo-[3.2.0]-heptane-6-sulfonic acid compounds substituted at the two position of the bicyclic ring with a heterocyclylaminocarbonyl group or a carbocyclylaminocarbonyl group are β-lactamase inhibitors. The compounds and their prodrugs and pharmaceutically acceptable salts are useful in the treatment of bacterial infections in combination with β-lactam antibiotics. In particular, the compounds are suitable for use with β-lactam antibiotics (e.g., imipenem and ceftazidime) against micro-organisms resistant to β-lactam antibiotics due to the presence of the β-lactamases.

Development of potent serotonin-3 (5-HT3) receptor antagonists. I. Structure-activity relationships of 2-alkoxy-4-amino-5-chlorobenzamide derivatives

A new series of 2-alkoxy-4-amino-5-chlorobenzamide derivatives hearing five- to seven-membered heteroalicyclic rings in the amine moiety was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity by assaying the ability to antagonize the yon Bezold-Jarisch reflex in rats. The five- to seven-membered heteroalicycles comprise pyrrolidine, morpholine, 1,4-thiazine, piperidine, piperazine, 1,4-oxazepine, 1,4- thiazepine, azepine, and 1,4-diazepine rings. Among them, some benzamide derivatives having a 1,4-diazepine ring showed a potent 5-HT3 receptor antagonistic activity. In particular, 4-amino-5-chloro-N-(1,4- dimethylhexahydro-1H-1,4-diazepin-6-yl)-2-ethoxyhenzamide (96) and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 103 showed potent 5-HT3 receptor antagonistic activity without 5-HT4 receptor binding affinity.