124267-25-0Relevant articles and documents
A copper-free palladium catalyzed cross coupling reaction of vinyl tosylates with terminal acetylenes
Fu, Xiaoyong,Zhang, Shuyi,Yin, Jianguo,Schumacher, Doris P.
, p. 6673 - 6676 (2002)
A copper-free palladium-catalyzed cross coupling of vinyl tosylate (2) and terminal acetylenes was investigated, affording a convenient and efficient method for construction of an sp-sp2 carbon-carbon bond. The tosylate (2) derived from 1,3-cyc
Synthesis and evaluation of novel α-fluorinated (E)-3-((6- methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyl oxime (ABP688) derivatives as metabotropic glutamate receptor subtype 5 PET radiotracers
Sephton, Selena Milicevic,Mu, Linjing,Schibli, Roger,Kraemer, Stefanie D.,Ametamey, Simon M.,Schweizer, W. Bernd
supporting information, p. 7154 - 7162,9 (2020/09/09)
In the search for an optimal fluorine-18-labeled positron emission tomography (PET) radiotracer for imaging metabotropic glutamate receptor subtype 5 (mGluR5), we have prepared a series of five α-fluorinated derivatives based on the ABP688 structural mani
Highly enantioselective and regioselective copper-catalyzed 1,4 addition of grignard reagents to cyclic enynones
Tissot, Matthieu,Perez Hernandez, Alexandra,Mueller, Daniel,Mauduit, Marc,Alexakis, Alexandre
, p. 1524 - 1527 (2011/05/04)
In this letter we describe an unusual result in terms of regioselectivity with respect to copper-catalyzed conjugate additions of various Grignard reagents to cyclic enynones. The use of Cu(OTf)2 and NHC ligand L1 as the catalyst combination in CH2Cl2 led to the unique formation of the 1,4 adduct. This selectivity does not follow the general trend previously observed in the literature using extended Michael acceptors. Moreover these reactions allowed for the creation of a quarternary stereogenic center with enantioselectivities up to 97% ee.
