1243654-89-8

Basic information

• Product Name: N-ethyl-N-nosyl-L-leucine methyl ester
• Synonyms: N-ethyl-N-nosyl-L-leucine methyl ester
• CAS NO: 1243654-89-8
• Molecular Weight: 358.415
• Mol File: 1243654-89-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-ethyl-N-nosyl-L-leucine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyl-N-nosyl-L-leucine methyl ester(1243654-89-8)
• EPA Substance Registry System: N-ethyl-N-nosyl-L-leucine methyl ester(1243654-89-8)

Safety Data

• Hazardous Substances Data: 1243654-89-8(Hazardous Substances Data)

Upstream product

• 368-39-8 triethyloxonium fluoroborate 
• 203873-66-9 (S)-methyl 4-methyl-2-(4-nitrophenylsulfonamido)pentanoate 

Relevant articles and documents

N-(4-nitrophenylsulfonyl)- And N-(fluorenylmethoxycarbonyl)-N-ethyl amino acid methyl esters - A practical approach

An efficient one-pot preparation of N-ethyl-N-4-nitrophenylsulfonyl (nosyl) amino acid methyl esters was accomplished by a simple N-ethylation reaction by using triethyloxonium tetrafluoroborate in the presence of N,N- diisopropylethylamine, The N-ethylated amino acid methyl esters are obtained with total retention of stereochemistry at the original chiral centers. To further broaden the scope of this methodology, the N-ethylated nosyl-protected compounds are easily converted in the more practical fluorenylmethyloxycarbonyl (Fmoc)-protected derivatives. The cleavage of methyl ester by using a mild and neutral method enables the preparation of N-ethyl amino acids that are building blocks suitable for introduction into a peptide chain. The methodology works well with both nosyl- and Fmoc-based solution-phase peptide synthesis.