124424-26-6

Basic information

• Product Name: 1-(3-azido-2,3-dideoxy-2-fluoroarabinofuranosyl)thymine
• Synonyms: 1-(3-azido-2,3-dideoxy-2-fluoroarabinofuranosyl)thymine
• CAS NO: 124424-26-6
• Molecular Formula: C10H12FN5O4
• Molecular Weight: 285.2317832
• Mol File: 124424-26-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 1-(3-azido-2,3-dideoxy-2-fluoroarabinofuranosyl)thymine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-azido-2,3-dideoxy-2-fluoroarabinofuranosyl)thymine(124424-26-6)
• EPA Substance Registry System: 1-(3-azido-2,3-dideoxy-2-fluoroarabinofuranosyl)thymine(124424-26-6)

Safety Data

• Hazardous Substances Data: 124424-26-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H12FN5O4/c1-4-2-16(10(19)13-8(4)18)9-6(11)7(14-15-12)5(3-17)20-9/h2,5-7,9,17H,3H2,1H3,(H,13,18,19)/t5-,6+,7-,9-/m1/s1

Upstream product

• 128114-99-8 2,3'-anhydro-1-(2-deoxy-2-fluoro-5-O-trityl-β-D-lyxofuranosyl)thymine 
• 128114-97-6 1-(2-deoxy-2-fluoro-5-O-trityl-β-D-arabinofuranosyl)thymine 
• 128114-98-7 1-(2-deoxy-2-fluoro-3-O-mesyl-5-O-triphenylmethyl-β-D-arabinofuranosyl)thymine 
• 69256-17-3 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine 
• 124424-31-3 O-2,3-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>thymine 
• 121353-88-6 1-<5-O-(monomethoxytrityl)-2-fluoro-2-deoxy-β-D-arabinofuransosyl>thymine 
• 124424-30-2 1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>thymine 
• 97614-44-3 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 97614-47-6 1-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)thymine 
• 144822-48-0 5′-O-(dimethoxytrityl)-2′-β-fluorothymidine 
• 97614-43-2 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose 
• 65-71-4 thymin 
• 132776-25-1 1-(3-azido-2,3-dideoxy-2-fluoro-5-O-trityl-β-D-ribofuranosyl)thymine 

Relevant articles and documents

S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS

Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.

Fluorinated sugar analogues of potential anti-HIV-1 nucleosides

In order to obtain agents with therapeutic indices superior to those of AZT, FLT, or D4T, several analogues of anti-HIV-1 nucleosides were synthesized. These include 2',3'-dideoxy-2',3'-difluoro-5-methyluridine (13), its arabino analogue 19, arabino-5-met

Synthesis and anti-HIV-1 activity of 2'-'up'-fluoro analogues of active anti-AIDS nucleosides 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (DDC)

1-(3-Azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)thymine (6, F-AZT) and 1-(2,3-dideoxy-2-fluoro-β-D-threopentofuranosyl)cytosine (12, F-DDC) were synthesized from the potent antiherpes virus nucleosides 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine