1245374-92-8

Basic information

• Product Name: cinacalcet base
• Synonyms: cinacalcet base
• CAS NO: 1245374-92-8
• Molecular Weight: 526.439
• Mol File: 1245374-92-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: cinacalcet base(CAS DataBase Reference)
• NIST Chemistry Reference: cinacalcet base(1245374-92-8)
• EPA Substance Registry System: cinacalcet base(1245374-92-8)

Safety Data

• Hazardous Substances Data: 1245374-92-8(Hazardous Substances Data)

Upstream product

• 129254-76-8 1-(3-bromopropyl)-3- (trifluoromethyl)benzene 
• 154318-44-2 (1R)-1-(1-naphthyl)-N-(phenylmethylene)ethanamine 
• 100-52-7 benzaldehyde 
• 3886-70-2 (R)-1-(1-Naphthyl)ethylamine 

Downstream Products

• 226256-56-0 cinacalcet 
• 364782-34-3 cinacalcet hydrochloride 
• 1271930-15-4 (R)-(1-naphthalen-1-ylethyl)-N,N-bis[3-(3-trifluoromethylphenyl)propyl]amine 

Relevant articles and documents

Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof

A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.