1246513-37-0

Basic information

• Product Name: 5-(3-fluorophenyl)-1-phenyl-1H-pyrazol-3-ol
• Synonyms: 5-(3-fluorophenyl)-1-phenyl-1H-pyrazol-3-ol
• CAS NO: 1246513-37-0
• Molecular Weight: 254.264
• Mol File: 1246513-37-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(3-fluorophenyl)-1-phenyl-1H-pyrazol-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-fluorophenyl)-1-phenyl-1H-pyrazol-3-ol(1246513-37-0)
• EPA Substance Registry System: 5-(3-fluorophenyl)-1-phenyl-1H-pyrazol-3-ol(1246513-37-0)

Safety Data

• Hazardous Substances Data: 1246513-37-0(Hazardous Substances Data)

Upstream product

• 1204575-42-7 5-(3-fluorophenyl)-1-phenylpyrazolidin-3-one 
• 87087-34-1 3-(3-fluorophenyl)acrylic acid methyl ester 
• 100-63-0 phenylhydrazine 

Downstream Products

• 1246513-46-1 ethyl 2-(5-(3-fluorophenyl)-1-phenyl-1H-pyrazol-3-yloxy)acetate 
• 1338378-15-6 4-chloro-5-(3-fluorophenyl)-1-phenyl-1H-pyrazol-3-ol 

Relevant articles and documents

Synthesis, crystal structure, and fungicidal activity of novel 1,5-diaryl-1H-pyrazol-3-Oxy derivatives containing oxyacetic acid or oxy(2-thioxothiazolidin-3-yl)ethanone moieties

A series of novel 1,5-diaryl-1H-pyrazol-3-oxy derivatives containing oxyacetic acid or oxy(2-thioxothiazolidin-3-yl)ethanone moieties were prepared from methyl 3-arylacrylates via a serial of reactions included addition-cyclization, oxidation, substitution, hydrolysis, and condensation. Their structures were confirmed by 1H-NMR, 13C-NMR, IR, and elemental analysis. In addition, the crystal structure of the compound 2-(1,5-diphenyl-1H-pyrazol-3-yloxy)-1-(2-thioxothiazolidin-3-yl)ethanone was determined by single crystal X-ray diffraction analysis. Bioassay results indicated that the compound 2-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yloxy)- 1-(2-thioxo-thiazolidin-3-yl)ethanone exhibited moderate inhibitory activity against Gibberella zeae at the dosage of 10 μg mL-1.

Synthesis, crystal structure, and fungicidal activity of novel 1,5-Diaryl-1H-pyrazol-3-oxyacetate derivatives

A series of ethyl 2-(1,5-diaryl-1H-pyrazol-3-yloxy)acetate derivatives (5a-5i) have been efficiently synthesized by the reaction of 1,5-diaryl-1H-pyrazol-3-ols (4a-4i) with ethyl 2-bromoacetate. The structures of the newly synthesized compounds were characterized by 1H NMR spectra and elemental analysis, and the crystal structure of the compound ethyl 2-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yloxy)acetate (5c) was determined by single crystal X-ray diffraction analysis. The compound 5c belongs to triclinic system with space group P(-1), a = 5.8170(12) A, b = 11.804(2) A, c = 12.783(2) A, α = 83.89(2)°, β = 89.24(3)°, γ = 89.73(3)°, Formula weight: 356.80, Triclinic V = 872.7(3) A3, Dc = 1.358 mg/m3, Z = 2, F (000) = 372. Bioassay results indicated that the compound ethyl 2-(5-(4-fluorophenyl)-1- phenyl-1H-pyrazol-3-yloxy)acetate (5d) exhibited moderate inhibitory activity against Gibberella zeae at the dosage of 10 μg/mL.