87087-34-1

Basic information

• Product Name: 2-Propenoic acid, 3-(3-fluorophenyl)-, methyl ester
• CAS NO: 87087-34-1
• Molecular Formula: C10H9FO2
• Molecular Weight: 180.179
• Mol File: 87087-34-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(3-fluorophenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(3-fluorophenyl)-, methyl ester(87087-34-1)
• EPA Substance Registry System: 2-Propenoic acid, 3-(3-fluorophenyl)-, methyl ester(87087-34-1)

Safety Data

• Hazardous Substances Data: 87087-34-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 20595-30-6 3-fluorocinnamic acid 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 456-48-4 3-Fluorobenzaldehyde 
• 96-32-2 bromoacetic acid methyl ester 
• 1067-74-9 Methyl diethylphosphonoacetate 

Downstream Products

• 125872-67-5 (E)-3-(3-fluorophenyl)prop-2-en-1-ol 
• 1246513-37-0 5-(3-fluorophenyl)-1-phenyl-1H-pyrazol-3-ol 
• 1338378-15-6 4-chloro-5-(3-fluorophenyl)-1-phenyl-1H-pyrazol-3-ol 
• 425704-52-5 methyl 3-(3-fluorophenyl)propanoate 
• 700-84-5 5-fluoro-1-indanone 
• 20595-30-6 3-fluorocinnamic acid 

Relevant articles and documents

Enantioselective Synthesis of Pyroglutamic Acid Esters from Glycinate via Carbonyl Catalysis

Direct α-functionalization of NH2-free glycinates with relatively weak electrophiles such as α,β-unsaturated esters still remains a big challenge in organic synthesis. With chiral pyridoxal 5 d as a carbonyl catalyst, direct asymmetric conjugated addition at the α-C of glycinate 1 a with α,β-unsaturated esters 2 has been successfully realized, to produce various chiral pyroglutamic acid esters 4 in 14–96 % yields with 81–97 % ee's after in situ lactamization. The trans and cis diastereomers can be obtained at the same time by chromatography and both of them can be easily converted into chiral 4-substituted pyrrolidin-2-ones such as Alzheimer's drug Rolipram (11) with the same absolute configuration via tert-butyl group removal and subsequent Barton decarboxylation.

Catalytic asymmetric bromochlorination of aromatic allylic alcohols promoted by multifunctional Schiff base ligands

It was found that the tridentate O,N,O-type Schiff base ligand bearing suitable substituents was a highly effective promoter in the catalytic asymmetric bromochlorination reaction, in which the corresponding aromatic bromochloroalcohols with vicinal halogen-bearing stereocenters were formed with perfect regioselectivity, with moderate to excellent enantioselectivities (up to 93% ee), and with good yields and chemoselectivities.

Synthesis, crystal structure, and fungicidal activity of novel 1,5-Diaryl-1H-pyrazol-3-oxyacetate derivatives

A series of ethyl 2-(1,5-diaryl-1H-pyrazol-3-yloxy)acetate derivatives (5a-5i) have been efficiently synthesized by the reaction of 1,5-diaryl-1H-pyrazol-3-ols (4a-4i) with ethyl 2-bromoacetate. The structures of the newly synthesized compounds were characterized by 1H NMR spectra and elemental analysis, and the crystal structure of the compound ethyl 2-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yloxy)acetate (5c) was determined by single crystal X-ray diffraction analysis. The compound 5c belongs to triclinic system with space group P(-1), a = 5.8170(12) A, b = 11.804(2) A, c = 12.783(2) A, α = 83.89(2)°, β = 89.24(3)°, γ = 89.73(3)°, Formula weight: 356.80, Triclinic V = 872.7(3) A3, Dc = 1.358 mg/m3, Z = 2, F (000) = 372. Bioassay results indicated that the compound ethyl 2-(5-(4-fluorophenyl)-1- phenyl-1H-pyrazol-3-yloxy)acetate (5d) exhibited moderate inhibitory activity against Gibberella zeae at the dosage of 10 μg/mL.