124956-01-0

Basic information

• Product Name: 4-(2-Methoxy-ethoxymethoxy)-3-methyl-benzaldehyde
• CAS NO: 124956-01-0
• Molecular Weight: 224.257
• Mol File: 124956-01-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-Methoxy-ethoxymethoxy)-3-methyl-benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Methoxy-ethoxymethoxy)-3-methyl-benzaldehyde(124956-01-0)
• EPA Substance Registry System: 4-(2-Methoxy-ethoxymethoxy)-3-methyl-benzaldehyde(124956-01-0)

Safety Data

• Hazardous Substances Data: 124956-01-0(Hazardous Substances Data)

Upstream product

• 3970-21-6 2-Methoxyethoxymethyl chloride 
• 15174-69-3 4-hydroxy-3-methyl-benzaldehyde 

Downstream Products

• 124956-34-9 (2E,4E)-5-[4-(2-Methoxy-ethoxymethoxy)-3-methyl-phenyl]-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide 
• 124956-13-4 5-[4-{(2-Methoxyethoxy)methoxy}-3-methylphenyl]-(2E, 4E)-2, 4-pentadienoic acid 

Relevant articles and documents

(2E,4E)-N-(4-(1H-indol-3-yl)piperidin-1-yl)alkyl-5-(substituted phenyl)-2,4-pentadienamides as antiallergic agents with antihistaminic and anti slow-reacting substance (SRS) activities

As an extension of our study aiming to discover a novel compound with dual activities against histamine and slow-reacting substance (SRS), we synthesized two types of indolylpiperidine derivatives, 3 and 4-20. Testing for in vivo antianaphylactic activity and for in vitro anti-SRS activity revealed that (2E,4E)-5-(3,5-dimethoxy-4-hydroxyphenyl)-N-(2-(4-(1H-indol-3-yl)piper idin-1-yl)ethyl)-2,4-pentadienamide (11) exhibited potent dual activities with ED50 = 0.89 mg/kg and IC50 = 1.43 μM, respectively. However, the plasma concentration of unchanged 11 was very low when administered orally in guinea pigs. This result can be explained by fast formation of a glucuronic acid conjugate.