124980-95-6

Basic information

• Product Name: 2-Propen-1-ol, 3-(4-fluorophenyl)-, (2E)-
• CAS NO: 124980-95-6
• Molecular Formula: C9H9FO
• Molecular Weight: 152.168
• Mol File: 124980-95-6.mol
• Article Data: 84

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-ol, 3-(4-fluorophenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-ol, 3-(4-fluorophenyl)-, (2E)-(124980-95-6)
• EPA Substance Registry System: 2-Propen-1-ol, 3-(4-fluorophenyl)-, (2E)-(124980-95-6)

Safety Data

• Hazardous Substances Data: 124980-95-6(Hazardous Substances Data)

Upstream product

• 5724-03-8 1-(4-fluorophenyl)allyl alcohol 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 31736-68-2 2-(4'-fluorophenyl)oxetane 
• 24393-50-8 ethyl 4-fluorocinnamate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 1737-16-2 1-allyl-4-fluorobenzene 
• 459-32-5 4-fluorocinnamic acid 
• 24654-55-5 trans-4-fluorocinnamaldehyde 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 96426-60-7 methyl (2E)-3-(4-fluorophenyl)-2-propenoate 
• 136265-10-6 ethyl 4-fluorocinnamate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 702-15-8 3-(4-fluorophenyl)propan-1-ol 
• 1137838-06-2 tert-butyl (E)-3-(4'-fluorophenyl)prop-2-en-1-yl carbonate 
• 1147334-94-8 C₉H₅FN₂O₃ 
• 1147334-68-6 4-(4-fluorophenyl)-3-(hydroxymethyl)-1,2,5-oxadiazole 2-oxide 
• 1096491-27-8 (E)-3-(4-fluorophenyl)-2-propenyl methyl malonate 
• 1304683-82-6 (2S,3S)-tert-butyl3-(4-fluorophenyl)-2-cyano-2-ethylpent-4-enoate 
• 1351469-23-2 C₁₀H₁₃FO₂ 
• 6992-87-6 1-(4-fluorophenyl)-3-bromoprop-1-ene 
• 1446654-76-7 C₂₉H₃₀FNO₄ 
• 1446653-19-5 (2S,4S)-1-(2,2-diphenylacetyl)-4-(3-(4-fluorophenyl)-propoxy)pyrrolidine-2-carboxylic acid 
• 205108-06-1 (E)-3-(4'-fluorophenyl)-2-propen-1-ol acetate 

Relevant articles and documents

Synthesis and in vitro pharmacological behavior of platinum(II) complexes containing 1,2-diamino-1-(4-fluorophenyl)-2-alkanol ligands

In continuation of our effort to optimize the pharmacological profile of [1,2-diamino-1,2-bis(4-fluorophenyl)ethane]dichloridoplatinum(II) complexes, we synthesized [1,2-diamino-1-(4-fluorophenyl)alkanol]dichloridoplatinum(II) analogs. The aim of this study was to evaluate the influence of hydroxyl groups at the C2 moiety on aqueous solubility, lipophilicity, cellular platinum accumulation, and cytotoxicity against MDA-MB-231, U-937, RAJI, and SC-1 cells as well as against cisplatin-sensitive and cisplatin-resistant A2780 and A2780cisR ovarian carcinoma cells. As expected, the OH groups improved the water solubility and decreased the lipophilicity of the neutral ligands, resulting in complexes with favorable pharmacokinetic properties. The cellular uptake of the compounds in MDA-MB-231 and U-937 cells proved to depend on the configuration and showed only a slight correlation with lipophilicity. The most active complexes were R,R/S,S configured, which points to a carrier-mediated mode of action. [threo-1,2-Diamino-1-(4-fluorophenyl)propan]dichloridoplatinum(II) and [threo-2,3-diamino-3-(4-fluorophenyl)propan-1-ol]dichloridoplatinum(II) possessed only low cross-resistance to cisplatin and were up to 10-fold more active in lymphoma cell lines.

Strong acid-catalyzed electrophilic ring expansion of oxetanes and sulfoxonium ylides

A strong protic acid-catalyzed electrophilic ring expansion of oxetanes into trans-2,3-disubstituted tetrahydrofuran derivatives using sulfoxonium ylides has been developed. This reaction produces functionalized trans-2,3-disubstituted tetrahydrofuran derivatives stereospecifically by using safe and stable sulfoxonium ylides without metal catalysts and the protection of inert gas.

Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones

Identifying the targets of bioactive small molecules is a challenging endeavor for which no general solution currently exists. Classical affinity purification experiments suffer from the need to functionalise a bioactive compound and link it to a solid support, which may interfere with target binding. A modern mass spectrometry-based proteomics technique that has partially circumvented this problem is thermal proteome profiling (TPP), which determines the effect of an unmodified small molecule on the thermal stability of the whole proteome simultaneously. Here, we use TPP to identify the mode-of-action of a newly-discovered autophagy inhibitor based on oxazolidinones often employed as chiral auxiliaries. Surprisingly, a significant portion of all ribosomal proteins were found to be destabilized by the inhibitor, highlighting the utility of this technology for determining a challenging mode-of-action.