125103-96-0

Basic information

• Product Name: (S)-5-phenyl-3-hydroxypentanenitrile
• Synonyms: (S)-5-phenyl-3-hydroxypentanenitrile
• CAS NO: 125103-96-0
• Molecular Weight: 175.23
• Mol File: 125103-96-0.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: (S)-5-phenyl-3-hydroxypentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-phenyl-3-hydroxypentanenitrile(125103-96-0)
• EPA Substance Registry System: (S)-5-phenyl-3-hydroxypentanenitrile(125103-96-0)

Safety Data

• Hazardous Substances Data: 125103-96-0(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 75-05-8 acetonitrile 
• 18293-53-3 2-trimethylsilylacetonitrile 
• 1410787-80-2 C₁₂H₁₃NO₃ 
• 157732-87-1 (4S)-2,2-dimethyl-4-(2-phenylethyl)-1,3-dioxolane 
• 124988-64-3 (S)-4-phenyl-1,2-butanediol 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 151-50-8 potassium cyanide 
• 118629-73-5 (S)-2-hydroxy-4-phenylbutyl 4-methylbenzenesulfonate 
• 125103-93-7 (+/-)-3-<(phenylthio)acetoxy>-5-phenylpentanenitrile 
• 38046-39-8 cyanomethylzinc bromide 
• 1446698-46-9 (dimethylsilyl)acetonitrile 
• 5765-44-6 5-methylisoxazole 
• 100-39-0 benzyl bromide 

Downstream Products

• 587-63-3 7,8-dihydrokawain 
• 182950-96-5 (6S)-6-(2-phenylethyl)dihydropyran-2,4⁽³⁾-dione 
• 1172101-79-9 (S)-(3-tert-butyldiphenylsilanyloxy)-5-phenylpentanenitrile 
• 862464-32-2 methyl (5S)-5-hydroxy-3-oxo-7-phenylheptanoate 

Relevant articles and documents

Highly Enantioselective Synthesis of β-Hydroxy Nitriles by the Cyanomethylation of Aldehydes using DPMPM as a Chiral Catalyst or Ligand

Optically active β-hydroxy nitriles in up to 93percent e.e. were obtained by the enantioselective addition of cyanomethylzinc bromide to aldehydes using DPMPM as a chiral catalyst or ligand.

Nucleophilic addition of α-(dimethylsilyl)nitriles to aldehydes and ketones

α-Alkylated (dimethylsilyl)acetonitriles (Me2HSiCR 3R4CN) react spontaneously with aldehydes in DMSO to give β-hydroxynitriles in good to high yields. The addition to ketones is effectively promoted by using MgCl2/su

N-Heterocyclic carbene-catalyzed cyanomethylation of aldehydes with TMSAN

N-Heterocyclic carbenes (NHCs) have been served as efficient catalysts for cyanomethylation of carbonyl compounds. In the presence of 5 mol % NHC, various aldehydes and 2,2,2-trifluoroacetophenone reacted with trimethylsilylacetonitrile (TMSAN) to give β-hydroxynitriles in moderate to high yields.