1251915-08-8

Basic information

• Product Name: C₂₂H₂₄N₂O₄S
• CAS NO: 1251915-08-8
• Molecular Weight: 412.51
• Mol File: 1251915-08-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₄N₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₄N₂O₄S(1251915-08-8)
• EPA Substance Registry System: C₂₂H₂₄N₂O₄S(1251915-08-8)

Safety Data

• Hazardous Substances Data: 1251915-08-8(Hazardous Substances Data)

Upstream product

• 4538-56-1 N,N-diphenylformamidine 
• 108-24-7 acetic anhydride 
• 146368-07-2 1-Ethyl-2,3,3-Trimethylindolenineninium 5-Sulfone 
• 64-19-7 acetic acid 
• 864131-95-3 N,N'-diphenylformamidine 
• 563-80-4 3-methyl-butan-2-one 
• 98-71-5 4-hydrazino-benzenesulfonic acid 
• 607-00-1 diphenylformamide 
• 75-36-5 acetyl chloride 

Downstream Products

• 1240125-28-3 C₃₁H₃₈N₂O₈S₂ 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR RETINAL INJURY DETECTION AND METHODS OF USING SAME

Described are compounds, compositions, and methods suitable for diagnosing individuals with eye injuries and/or diseases. The compounds of the present disclosure have fluorescent groups and bis-dipicolylamine groups, which may be substituted or unsubstituted. The fluorescent group and bis-dipicolylamine group are connected by linking groups. The compositions may be formulated and administered as an eye drop. The methods may be used to track and/or label dying cells associated with eye injuries and/or diseases, such as, for example, retinal degenerations including, but not limited to, retinitis pigmentosa, glaucoma, diabetic retinopathy, and age-related macular degeneration.

Bioorthogonally Applicable Fluorogenic Cyanine-Tetrazines for No-Wash Super-Resolution Imaging

The synthesis, fluorogenic characterization, and labeling application of four tetrazine-quenched cyanine probes with emission maxima in the red-far red range is reported. Fluorescence of the cyanine-cores is quenched via through-bond-energy-transfer (TBET) exerted by a bioorthogonal tetrazine unit. Upon bioorthogonal labeling reaction with cyclooctyne tagged proteins, the quenching effect ceases, and thus the fluorescence reinstates, resulting in an increase in fluorescence intensity. As a rare example among indocyanines, one of our new probes was found suitable in STED-based super-resolution imaging. The applicability of this fluorogenic Tet-Cy3 probe was therefore further demonstrated in the bioorthogonal labeling of cytoskeletal protein, actin, with subsequent super-resolution microscopy (STED) imaging even under no-wash conditions.

NOVEL CYANINE COMPOUND FOR LABELING BIOMOLECULE AND PREPARATION METHOD THEREOF

The present invention relates to a novel cyanine compound which is represented by chemical formula 1, and is used for biomolecular labeling. The present invention further relates to a production method thereof. In the chemical formula 1, R_1, R_2, R_3, R_4, B, m, and n are the same as defined in the present specification.COPYRIGHT KIPO 2017