1253075-41-0

Basic information

• Product Name: diethyl 2,6-bis(difluoromethyl)-4-(4-chloro-2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 1253075-41-0
• Molecular Weight: 503.801
• Mol File: 1253075-41-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl 2,6-bis(difluoromethyl)-4-(4-chloro-2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2,6-bis(difluoromethyl)-4-(4-chloro-2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate(1253075-41-0)
• EPA Substance Registry System: diethyl 2,6-bis(difluoromethyl)-4-(4-chloro-2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate(1253075-41-0)

Safety Data

• Hazardous Substances Data: 1253075-41-0(Hazardous Substances Data)

Upstream product

• 352-24-9 ethyl 4,4-difluoro-3-oxobutyrate 
• 320-43-4 4-chloro-2-(trifluoromethyl)benzaldehyde 
• 631-61-8 ammonium acetate 

Relevant articles and documents

An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions

The difluoromethyl-containing Hantzsch 1,4-dihydropyridines were synthesized in good yields by a one-pot cyclocondensation of ethyl difluoroacetoacetate (EDFAA), a variety of aromatic aldehydes and ammonium acetate under solvent and catalyst free conditions. The comparison of reaction conditions and products was made among the different 1,3-carbonyl substrates (ethyl acetoacetate, ethyl difluoroacetoacetate and ethyl trifluoroacetoacetate) for the Hantzsch reaction.