320-43-4

Basic information

• Product Name: 4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE
• Synonyms: 4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE;2-TRIFLUOROMETHYL-4-CHLOROBENZALDEHYDE;2-(Trifluoromthyl)-4-Chlorobenzaldehyde;4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE, 97%+;Benzaldehyde, 4-chloro-2-(trifluoromethyl)-;4-Chloro-2-(trifluoromethyl)benzald
• CAS NO: 320-43-4
• Molecular Formula: C₈H₄ClF₃O
• Molecular Weight: 208.56
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde
• Mol File: 320-43-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 218.5 °C at 760 mmHg
• Flash Point: 85.9 °C
• Appearance: /
• Density: 1.423 g/cm³
• Vapor Pressure: 0.034mmHg at 25°C
• Refractive Index: 1.4960
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE(320-43-4)
• EPA Substance Registry System: 4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE(320-43-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• Hazardous Substances Data: 320-43-4(Hazardous Substances Data)

Usage

General Description

4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE is a chemical compound with the molecular formula C8H4ClF3O. It is a benzaldehyde derivative with a chloro and a trifluoromethyl group attached to the benzene ring. 4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE is commonly used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also used as a building block for the synthesis of various aromatic compounds. 4-CHLORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE is a colorless to pale yellow liquid with a strong odor, and it should be handled and stored with care due to its potential irritant and harmful effects.

InChI:InChI=1/C7H4BrF3O/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3,12H

Upstream product

• 320-41-2 4-chloro-2-(trifluoromethyl)benzonitrile 
• 707-72-2 o-trifluoromethyl-α,α-dichlorotoluene 
• 157229-44-2 o-trifluoromethyl-4-chloro-α,α-dichlorotoluene 
• 615-60-1 4-chloro-1,2-dimethylbenzene 

Downstream Products

• 211796-64-4 4-formyl-3-(trifluoromethyl)benzonitrile 
• 1203486-41-2 4-chloro-1-(dimethoxymethyl)-2-(trifluoromethyl)benzene 
• 1253075-41-0 diethyl 2,6-bis(difluoromethyl)-4-(4-chloro-2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 1259500-54-3 C₁₅H₁₄ClF₃O 
• 771570-05-9 C₁₁H₄ClF₃N₂ 
• 1259500-55-4 C₁₅H₁₆ClF₃O 
• 1259500-51-0 5-(2-trifluoromethyl-4-chloro-benzyl)-1-(5-mercapto-[1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol 
• 1259500-56-5 5-(2-trifluoromethyl-4-chloro-benzyl)-1-([1,2,4]triazol-1-ylmethyl)-2,2-dimethylcyclopentanol 
• 1204654-04-5 C₂₁H₁₅Cl₂F₃N₆O₂ 
• 1227682-50-9 C₂₆H₁₇Cl₂F₃N₆O₃ 
• 1043494-63-8 4-(4-chloro-2-trifluoromethylphenyl)-4,5-dihydrooxazol-2-ylamine 
• 1422127-52-3 C₂₁H₂₅ClF₃N₃O₂S 
• 1422127-27-2 C₂₀H₁₉ClF₃N₃OS 
• 1442445-64-8 (R)-5-bromo-N-(1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)benzene-1,2-diamine 

Relevant articles and documents

Intermediate compound for preparing 4-chloro-2-trifluoromethyl-acetophenone as well as preparation method and application of intermediate compound

The invention relates to an intermediate compound for preparing 4-chloro-2-trifluoromethyl-acetophenone as well as a preparation method and application of the intermediate compound. The intermediate compound is 2-(4-chloro-2-(trifluoromethyl) benzoyl) malonate, 3, 4-dimethylchlorobenzene is taken as an initial raw material, and the intermediate compound is obtained by chlorination, fluorine-chlorine exchange reaction, hydrolysis, continuous chlorination and coupling with malonate. The intermediate compound 2-(4-chloro-2-(trifluoromethyl) benzoyl) malonate is subjected to hydrolysis decarboxylation to obtain 4-chloro-2-trifluoromethyl-acetophenone, the raw materials in the route are easy to obtain, dangerous reactions such as nitration and Grignard reaction are avoided, and the method is suitable for industrial production.

Preparation method of o-trifluoromethyl-4-halogenobenzaldehyde and intermediate of o-trifluoromethyl-4-halogenobenzaldehyde

The invention discloses a preparation method of o-trifluoromethyl-4-halogenobenzaldehyde and an intermediate of the o-trifluoromethyl-4-halogenobenzaldehyde. The preparation method comprises that under solvent-free conditions, in the presence of an acid a