320-41-2

Basic information

• Product Name: 4-Chloro-2-(trifluoromethyl)benzonitrile
• Synonyms: 4-chloro-2-(trifluoronethyl)benzonitrile;2-trifluoromethyl-4-chlorophenyl-carbonitrile;2-TRIFLUOROMETHYL-4-CHLOROBENZONITRILE;5-CHLORO-2-CYANOBENZOTRIFLUORIDE;4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE;3-Chloro-6-cyanobenzotrifluoride;5-Chloro-2-cyanobenzotrifluoride 98%;5-Chloro-2-cyanobenzotrifluoride98%
• CAS NO: 320-41-2
• Molecular Formula: C₈H₃ClF₃N
• Molecular Weight: 205.56
• Product Categories: Fluorobenzene;Fluorine series
• Mol File: 320-41-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 109/10mm
• Flash Point: 87.5 °C
• Appearance: /
• Density: 1.43 g/cm³
• Vapor Pressure: 0.109mmHg at 25°C
• Refractive Index: 1.4950
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Chloro-2-(trifluoromethyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-(trifluoromethyl)benzonitrile(320-41-2)
• EPA Substance Registry System: 4-Chloro-2-(trifluoromethyl)benzonitrile(320-41-2)

Safety Data

• Hazard Codes: T
• RIDADR: UN3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 320-41-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow liquid

InChI:InChI=1/C8H3ClF3N/c9-6-2-1-5(4-13)7(3-6)8(10,11)12/h1-3H

Upstream product

• 108-20-3 di-isopropyl ether 
• 23399-77-1 4-chloro-2-trifluoromethyliodobenzene 
• 557-21-1 dicyanozinc 
• 623-03-0 4-Cyanochlorobenzene 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 143782-20-1 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile 
• 320-43-4 4-chloro-2-(trifluoromethyl)benzaldehyde 
• 115591-65-6 methyl 4-chloro-2-(trifluoromethyl)benzoate 
• 142994-09-0 4-chloro-2-(trifluoromethyl)benzoic acid 
• 320-42-3 4-hydroxy-2-(trifluoromethyl)benzonitrile 

Relevant articles and documents

Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent

Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions. (Chemical Equation Presented).

Phenylimidazolidine preparation process

A subject of the invention is a preparation process for the products of formula (I): STR1 in which R1 and R2 represent in particular hydrogen, cyano, halogen or amino,R3 represents in particular hydrogen or hydroxyl alkyl, R4 and R5 represent in particular optionally substituted alkyl, X and y represent oxygen or sulphur, characterized in that a product of formula (A): STR2 is prepared in which W represents a halogen atom or a hydantoin derivative, which is subjected to various reactions in order to obtain the products of formula (I), all their isomers and their salts.