125311-44-6Relevant articles and documents
CONDENSATION REACTIONS OF 2,4- AND 2,6-DIMETHYLPYRIDINES AND THEIR 1-OXIDES
Silhankova, Alexandra,Hulvova, Jana,Trska, Petr,Ferles, Miloslav
, p. 1687 - 1704 (2007/10/02)
Using the reactions of 2,4- and 2,6-dimethylpyridine-1-oxides with aromatic and heteroaromatic aldehydes under catalysis with potassium tert-butoxide (E)-aryl- and (E)-heteroarylethenylpyridine-1-oxides IIIa-IIIe, IVa-IVc, Va, Vb respectively, were prepared. 1-Oxides IIIg, IVd, IVe and Vc were obtained from the appropriate pyridine bases by oxidation with peracetic acid.Condensation of 2,4- and 2,6-dimethylpyridines with 3-pyridinecarbaldehyde gives a mixture of bases VIa and VIc, and VIb and VId, respectively.On Claisen condensation of 2,6- or 2,4-dimethylpyridine-1-oxide with diethyl oxalate in the presence of sodium hydride and potassium tert-butoxide lactone XIIa and XIIb is formed in addition to α-keto ester XIa and XIb, respectively.From esters XIa and XIb amides XId and XIe were prepared.