125313-60-2 Usage
Description
3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, also known as Bisindolylmaleimides, is a compound with protein kinase C inhibitor activity. It is characterized by its red solid appearance and is derived from the chemical class of indole alkaloids.
Uses
Used in Pharmaceutical Industry:
3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione is used as a protein kinase C inhibitor for the development of pharmaceuticals targeting various diseases. Its ability to inhibit protein kinase C makes it a potential candidate for therapeutic applications in cancer treatment and other conditions where protein kinase C plays a significant role in disease progression.
Used in Research and Development:
In the field of research and development, 3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione serves as a valuable compound for studying the mechanisms of protein kinase C and its role in cellular processes. This knowledge can be applied to develop new drugs and therapies for a range of diseases.
Used in Drug Synthesis:
3-[1-(3-Hydroxypropyl)-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione is also used as a key intermediate in the synthesis of various drugs, particularly those targeting protein kinase C. Its unique chemical structure allows for the development of novel compounds with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 125313-60-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,3,1 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 125313-60:
(8*1)+(7*2)+(6*5)+(5*3)+(4*1)+(3*3)+(2*6)+(1*0)=92
92 % 10 = 2
So 125313-60-2 is a valid CAS Registry Number.
125313-60-2Relevant articles and documents
Inhibitors of Protein Kinase C. 2. Substituted Bisindolylmaleimides with Improved Potency and Selectivity
Davis, Peter D.,Elliot, Lucy H.,Harris, William,Hill, Christopher H.,Hurst, Steven A.,et al.
, p. 994 - 1001 (2007/10/02)
A hypothetical mode of inhibition of protein kinase C (PKC) by the natural product staurosporine has been used as a basis for the design of substituted bisindolylmaleimides with improved potency over the parent compound.Structure-activity relationships were consistent with the interaction of a cationic group in the inhibitor with a carboxylate group in the enzyme, and the most potent compound had a Ki of 3 nM.The inhibitors were competitive with ATP but inhibited cAMP-dependent protein kinase (PKA) only at much higher concentrations despite the extensive sequence homology between ATP-binding regions of PKA and PKC.There compounds were evaluated further and found to inhibit a human allogeneic mixed lymphocyte reaction pointing to the potential utility of PKC inhibitors in immunosuppressive therapy.One of these compounds was orally absorbed in the rat and represents an attractive lead in the development of PKC inhibitors as drugs.
