125314-97-8 Usage
Description
3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate is a complex organic compound belonging to the class of Bisindolylmaleimides. It is characterized by its red solid appearance and possesses protein kinase C inhibitor activity, which makes it a potential candidate for various pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate is used as a protein kinase C inhibitor for its potential role in the development and treatment of various diseases. Its ability to inhibit protein kinase C makes it a valuable compound for research and development in the pharmaceutical industry, particularly in the areas of cancer therapy and other conditions where protein kinase C plays a significant role.
Used in Research and Development:
In the field of research and development, 3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate serves as a valuable tool for studying the mechanisms of protein kinase C and its involvement in cellular processes. 3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate can be used to investigate the effects of protein kinase C inhibition on cell signaling pathways, which may lead to the discovery of new therapeutic targets and strategies for treating diseases.
Used in Drug Design and Synthesis:
3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate can be utilized in the design and synthesis of new drugs targeting protein kinase C. Its unique chemical structure and properties make it a promising starting point for the development of novel inhibitors with improved potency, selectivity, and pharmacokinetic profiles. 3-[1-[3-(Hydroxy)propyl]-1H-indol-3-yl]-4-(1-Methyl-1H-indol-3-yl)-2,5-furandione Acetate can be further modified and optimized to create more effective and safer drugs for various therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 125314-97-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,3,1 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 125314-97:
(8*1)+(7*2)+(6*5)+(5*3)+(4*1)+(3*4)+(2*9)+(1*7)=108
108 % 10 = 8
So 125314-97-8 is a valid CAS Registry Number.
125314-97-8Relevant articles and documents
Inhibitors of Protein Kinase C. 2. Substituted Bisindolylmaleimides with Improved Potency and Selectivity
Davis, Peter D.,Elliot, Lucy H.,Harris, William,Hill, Christopher H.,Hurst, Steven A.,et al.
, p. 994 - 1001 (2007/10/02)
A hypothetical mode of inhibition of protein kinase C (PKC) by the natural product staurosporine has been used as a basis for the design of substituted bisindolylmaleimides with improved potency over the parent compound.Structure-activity relationships were consistent with the interaction of a cationic group in the inhibitor with a carboxylate group in the enzyme, and the most potent compound had a Ki of 3 nM.The inhibitors were competitive with ATP but inhibited cAMP-dependent protein kinase (PKA) only at much higher concentrations despite the extensive sequence homology between ATP-binding regions of PKA and PKC.There compounds were evaluated further and found to inhibit a human allogeneic mixed lymphocyte reaction pointing to the potential utility of PKC inhibitors in immunosuppressive therapy.One of these compounds was orally absorbed in the rat and represents an attractive lead in the development of PKC inhibitors as drugs.
