1254473-68-1

Basic information

• Product Name: (R)-1-(3,5-dichloropyridin-4-yl)ethanol
• Synonyms: (R)-1-(3,5-dichloropyridin-4-yl)ethanol
• CAS NO: 1254473-68-1
• Molecular Formula: C7H7Cl2NO
• Molecular Weight: 192.04258
• Mol File: 1254473-68-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 276.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.395±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.16±0.20(Predicted)
• CAS DataBase Reference: (R)-1-(3,5-dichloropyridin-4-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(3,5-dichloropyridin-4-yl)ethanol(1254473-68-1)
• EPA Substance Registry System: (R)-1-(3,5-dichloropyridin-4-yl)ethanol(1254473-68-1)

Safety Data

• Hazardous Substances Data: 1254473-68-1(Hazardous Substances Data)

Usage

General Description

(R)-1-(3,5-dichloropyridin-4-yl)ethanol is a chemical compound with the molecular formula C7H7Cl2NO. It is a chiral alcohol with a pyridine ring and two chlorine atoms attached to it. (R)-1-(3,5-dichloropyridin-4-yl)ethanol is used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and agrochemicals. It has been studied for its potential use as an anti-inflammatory and anti-cancer agent. Additionally, it has also been investigated for its potential antifungal and antibacterial properties. However, further research is needed to fully understand its potential therapeutic applications and biological activities.

Upstream product

• 2457-47-8 3,5-dichloropyridine 
• 75-07-0 acetaldehyde 
• 676-58-4 methylmagnesium chloride 
• 136590-83-5 3,5-dichloropyridine-4-carboxaldehyde 
• 1254473-66-9 1-(3,5-dichloropyridin-4-yl)ethan-1-ol 
• 402561-66-4 methyl 3,5-dichloro-4-pyridyl ketone 
• 1370347-50-4 (S)-1-(3,5-dichloropyridin-4-yl)ethan-1-ol 

Relevant articles and documents

VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS

FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.

Discovery of 3-(5′-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation

Fibroblast growth factor receptor (FGFR) represents an attractive oncology target for cancer therapy in view of its critical role in promoting cancer formation and progression, as well as causing resistance to approved therapies. In this article, we describe the identification of the potent pan-FGFR inhibitor (R)-21c (FGFR1-4 IC50 values of 0.9, 2.0, 2.0, and 6.1 nM, respectively). Compound (R)-21c exhibited excellent in vitro inhibitory activity against a panel of FGFR-amplified cell lines. Western blot analysis demonstrated that (R)-21c suppressed FGF/FGFR and downstream signaling pathways at nanomolar concentrations. Moreover, (R)-21c provided nearly complete inhibition of tumor growth (96.9% TGI) in NCI-H1581 (FGFR1-amplified) xenograft mice model at the dose of 10 mg/kg/qd via oral administration.

PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2

A compound of formula la or formula lb, or a pharmaceutically acceptable salt or ester thereof, wherein R1 is selected from: aryl; heteroaryl; -NHR3; fused aryl-C4-7-heterocycloalkyl; - CONR4R5; -NHCO