1370347-50-4

Basic information

• Product Name: (S)- 1 -(3,5-Dichloropyridin-4-yl)ethanol
• Synonyms: (S)- 1 -(3,5-Dichloropyridin-4-yl)ethanol;4-Pyridinemethanol, 3,5-dichloro-α-methyl-, (αS)-;(alphaS)-3,5-Dichloro-alpha-methyl-4-pyridinemethanol;(S)-1-(3,5-dichloropyridin-4-yl)ethan-1-ol;EOS-62118
• CAS NO: 1370347-50-4
• Molecular Formula: C7H7Cl2NO
• Molecular Weight: 192.04258
• Mol File: 1370347-50-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 276.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.395±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.16±0.20(Predicted)
• CAS DataBase Reference: (S)- 1 -(3,5-Dichloropyridin-4-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)- 1 -(3,5-Dichloropyridin-4-yl)ethanol(1370347-50-4)
• EPA Substance Registry System: (S)- 1 -(3,5-Dichloropyridin-4-yl)ethanol(1370347-50-4)

Safety Data

• Hazardous Substances Data: 1370347-50-4(Hazardous Substances Data)

Usage

Description

(S)-1-(3,5-Dichloropyridin-4-yl)ethanol is an organic compound characterized by its unique molecular structure, featuring a dichloro-pyridinyl group attached to an ethanol molecule. (S)1 -(3,5-Dichloropyridin-4-yl)ethanol is known for its potential applications in the pharmaceutical industry, particularly in the development of cancer treatments.

Uses

Used in Pharmaceutical Industry:
(S)-1-(3,5-Dichloropyridin-4-yl)ethanol is used as a key intermediate compound for the synthesis of (R)-(E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol. This synthesized compound has demonstrated potential in the treatment of cancer, making (S)-1-(3,5-Dichloropyridin-4-yl)ethanol a valuable component in the development of novel cancer therapies.
The application of (S)-1-(3,5-Dichloropyridin-4-yl)ethanol in the pharmaceutical industry is primarily due to its role in the synthesis of a compound with potential anti-cancer properties. By serving as a crucial intermediate in the production process, it contributes to the ongoing efforts to develop new and effective treatments for various types of cancer.

InChI:InChI=1S/C7H7Cl2NO/c1-4(11)7-5(8)2-10-3-6(7)9/h2-4,11H,1H3/t4-/m0/s1

Upstream product

• 1254473-66-9 1-(3,5-dichloropyridin-4-yl)ethan-1-ol 
• 2457-47-8 3,5-dichloropyridine 
• 402561-66-4 methyl 3,5-dichloro-4-pyridyl ketone 

Downstream Products

• 1254473-68-1 (R)-1-(3,5-dichloropyridin-4-yl)ethan-1-ol 

Relevant articles and documents

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A chiral 1 - (3,5- two chloropyridine -4-yl)-ethanol synthesis method

The invention discloses an asymmetric synthesis method of 1-(3,5-dichloropyridine-4-yl)-ethanol. The asymmetric synthesis method comprises the following steps: (A) under an action of lithium amide, carrying out a reaction of 3,5-dichloropyridine (I) with acetaldehyde to generate (+/-)-1-(3,5-dichloropyridine-4-yl)-ethanol (II); (B) under an action of an oxidant, allowing (+/-)-1-(3,5-dichloropyridine-4-yl)-ethanol (II) to generate 1-(3,5-dichloropyridine-4-yl)-ethyl ketone (III); and (C) in the presence of a chiral ligand, carrying out a reaction of 1-(3,5-dichloropyridine-4-yl)-ethyl ketone with a borane reagent, and thus obtaining the 1-(3,5-dichloropyridine-4-yl)-ethanol (IV) having a single optical isomer. Compared with traditional chiral column separation of (+/-)-1-(3,5-dichloropyridine-4-yl)-ethanol, the method has the prominent advantages that: (1) the reactions are simple, the operation is easy, the total yield is high, and the optical purity is more than 98%; (2) the industrial preparation period is shortened obviously, and equipment requirements are low; and (3) the preparation cost is low, and the method is suitable for industrial production.

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