1254691-84-3

Basic information

• Product Name: ethyl 2-phenoxypyridine-3-carboxylate
• Synonyms: ethyl 2-phenoxypyridine-3-carboxylate
• CAS NO: 1254691-84-3
• Molecular Weight: 243.262
• Mol File: 1254691-84-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 2-phenoxypyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-phenoxypyridine-3-carboxylate(1254691-84-3)
• EPA Substance Registry System: ethyl 2-phenoxypyridine-3-carboxylate(1254691-84-3)

Safety Data

• Hazardous Substances Data: 1254691-84-3(Hazardous Substances Data)

Upstream product

• 1452-94-4 ethyl 2-chloronicotinate 
• 108-95-2 phenol 
• 64-17-5 ethanol 
• 35620-71-4 2-phenoxypyridine-3-carboxylic acid 
• 2942-59-8 2-chloronicotinic acid 

Downstream Products

• 175135-01-0 2-phenoxynicotinic acid hydrazide 
• 474973-64-3 benzylidene-2-phenoxynicotinic acid hydrazide 
• 1254691-87-6 (4-methylbenzylidene)-2-phenoxynicotinic acid hydrazide 
• 1254691-89-8 (4-dimethylaminobenzylidene)-2-phenoxynicotinic acid hydrazide 
• 1254691-90-1 (4-nitrobenzylidene)-2-phenoxynicotinic acid hydrazide 
• 1254691-91-2 (2,4-dimethoxybenzylidene)-2-phenoxynicotinic acid hydrazide 
• 1254691-92-3 2-phenoxy-N'-(thiophen-2-ylmethylidene)nicotinic acid hydrazide 
• 474973-44-9 2-phenoxy-N'-(pyridin-4-ylmethylidene)nicotinic acid hydrazide 
• 474973-43-8 2-phenoxy-N'-(pyridin-3-ylmethylidene)nicotinic acid hydrazide 
• 1254692-03-9 (1-(4-chlorophenyl)ethylidene)-2-phenoxynicotinic acid hydrazide 
• 1254692-04-0 (1-(4-methoxyphenyl)ethylidene)-2-phenoxynicotinic acid hydrazide 
• 35620-71-4 2-phenoxypyridine-3-carboxylic acid 
• 1239353-80-0 N-[(1R)-2-(4-methylpiperazin-1-yl)-2-oxo-1-{[(phenylmethyl)oxy]methyl}ethyl]-2-(phenyloxy)pyridine-3-carboxamide 

Relevant articles and documents

Carboxyl radical-assisted 1,5-aryl migration through Smiles rearrangement

We report herein, a silver(i)-catalyzed Smiles rearrangement of 2-aryloxy- or 2-(arylthio)benzoic acids to provide aryl-2-hydroxybenzoate or aryl-2-mercaptobenzoate dimer, respectively, through 1,5-aryl migration from oxygen or sulfur to carboxylate oxygen. Mechanistically, the aryl ether moiety undergoes an intramolecular ipso attack by the carboxyl radical followed by a C-O or C-S bond cleavage. Aryl-2-mercaptobenzoates undergo oxidative dimerization through a thiol moiety in situ.

Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents

A series of 2-phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds having an unsubstituted phenyl/4-pyridyl or C-4 methoxy substituent on the terminal phenyl ring showed moderate to high analgesic or antiinflammatory activity in comparison to mefenamic acid as the reference drug. The compounds with highest anti-inflammatory activity were subjected to in vitro COX-1/COX-2 inhibition assays and showed moderate to good COX-1 and weak COX-2 inhibition activities.