474973-64-3Relevant articles and documents
Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents
Moradi, Alireza,Navidpour, Latifeh,Amini, Mohsen,Sadeghian, Hamid,Shadnia, Hooman,Firouzi, Omidreza,Miri, Ramin,Ebrahimi, Seyed Esmaeil Sadat,Abdollahi, Mohammad,Zahmatkesh, Mona Haddad,Shafiee, Abbas
, p. 509 - 518 (2011/05/06)
A series of 2-phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds having an unsubstituted phenyl/4-pyridyl or C-4 methoxy substituent on the terminal phenyl ring showed moderate to high analgesic or antiinflammatory activity in comparison to mefenamic acid as the reference drug. The compounds with highest anti-inflammatory activity were subjected to in vitro COX-1/COX-2 inhibition assays and showed moderate to good COX-1 and weak COX-2 inhibition activities.
