125743-96-6

Basic information

• Product Name: 4'-acetamino-2-methyl-4-nitro-diphenylsulfone
• Synonyms: 4'-acetamino-2-methyl-4-nitro-diphenylsulfone
• CAS NO: 125743-96-6
• Molecular Weight: 334.353
• Mol File: 125743-96-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-acetamino-2-methyl-4-nitro-diphenylsulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-acetamino-2-methyl-4-nitro-diphenylsulfone(125743-96-6)
• EPA Substance Registry System: 4'-acetamino-2-methyl-4-nitro-diphenylsulfone(125743-96-6)

Safety Data

• Hazardous Substances Data: 125743-96-6(Hazardous Substances Data)

Upstream product

• 946-94-1 S-[4-(acetylamino)phenyl] ethanethioate 
• 100-00-5 4-chlorobenzonitrile 
• 99-52-5 2-methyl-4-nitro-benzenamine 
• 13290-74-9 1-chloro-2-methyl-4-nitrobenzene 
• 15898-43-8 sodium 4-acetamidobenzenesulfinate 
• 855931-99-6 acetic acid-[4-(2-methyl-4-nitro-phenylsulfanyl)-anilide] 

Downstream Products

• 101513-47-7 4'-acetamino-2-methyl-4-(N-n-propyl-tosylamino)-diphenylsulfone 
• 125744-05-0 4'-acetamino-2-methyl-4-tosylamino-diphenylsulfone 
• 125744-06-1 4'-acetamino-2-methyl-4-n-propylamino-diphenylsulfone 
• 101513-21-7 4'-amino-2-methyl-4-n-propylamino-diphenylsulfone 
• 125743-99-9 4'-acetamino-4-amino-2-methyl-diphenylsulfone 

Relevant articles and documents

Preparation and biological activity of new substituted antimalarial diaminodiphenylsulfones

Starting from 4,4'-diamino-diphenylsulfone (DDS) as a lead structure, new 2-substituted analogues as well as new 2-substituted 4-alkylamino-4'-amino diphenylsulfones have been designed and synthesized in different ways. This has led to compounds the inhibitory activity of which against 7,8-dihydropteroic acid synthase of plasmodia and mycobacteria is clearly superior to that of sulfadoxine and in most cases to that of DDS. Of special interest is 4'-amino-4-n-propylamino-2-methyl-diphenylsulfone. Together with inhibitors of 7,8-dihydrofolate reductase in vitro and in vivo it possesses a marked synergistic inhibitory activity against plasmodia. In contrast to DDS in doses up to 200 mg/kg p.o. (cat) no methemoglobin formation is observed. The compound has been selected for further studies.